Objective. To study the functional state of the ovary, uterus, thymus and lymph nodes (inguinal) in animals with experimental immune complex-mediated inflammation in the conditions of the introduction of the substance zero-valent iron nanoparticles (nZVI). Material and methods. Changes in the functional state of the reproductive system were evaluated: 1) in vitro meiotic maturation of oocytes extracted from the ovary, 2) the viability of the follicular cells, 3) contraction of ovarian and cervical departments of the uterus (the amplitude, contractility index, the rate of reduction (CVmax) relaxation speed (RVmax), rate reductions. Changes in the functional state of organs of the immune system were evaluated: 1) the viability of thymus cells and lymph nodes, 2) damage to the nuclear DNA of the thymus and lymph node cells. We used in this work nanoparticle zero valent iron medium sized spherical shape of 40 nm with 100% iron content in the composition of the particle. To simulate experimental immune complex-mediated inflammation animals have been immunized by increasing doses of antigen - bovine serum albumin (BSA, Sigma, USA) once a week for 6 weeks, the animals were injected nZVI for 1 hour before each immunization, in a dose of 1.68 mg/kg. Results and conclusion. In terms of immune inflammation (associated disorders, in particular, immune complex-mediated inflammation) nZVI inhibits oocytes meiotic maturation and uterine contractility. The nZVI effect on thymus cells and lymph nodes requires further study.