The comparative analysis of chromosomal anomalies in human preimplantation embryos and spontaneous abortus

Mikitenko D.A.

GU "Institut gigieny i meditsinskoĭ kologii im. A.N. Marzeeva Natsional'noĭ akademii meditsinskikh nauk Ukrainy", Kiev, Ukraina

Pilip L.Ia.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev

Spinenko L.A.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev

Lavrova E.V.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev

Zukin V.D.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev, Ukraina

The comparative analysis of chromosomal anomalies in human preimplantation embryos and spontaneous abortus

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Mikitenko D.A., Pilip L.Ia., Spinenko L.A., Lavrova E.V., Zukin V.D.

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Journal: Russian Journal of Human Reproduction. 2013;(6): 59‑64

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Mikitenko DA, Pilip LIa, Spinenko LA, Lavrova EV, Zukin VD. The comparative analysis of chromosomal anomalies in human preimplantation embryos and spontaneous abortus. Russian Journal of Human Reproduction. 2013;(6):59‑64. (In Russ.)

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The frequency and structure of chromosomal abnormalities in embryos of patients with multiple implantation failures in assisted reproduction programs were compared to those detected in the products of conception in first trimester miscarriages. Chromosomal abnormalities were detected in 43.2% of miscarriage products and in 51.01% of human blastocysts. Our results highlight the importance of preimplantation aneuploidy screening of all chromosomes in embryos of patients with multiple implantation failures in assisted reproduction cycles.

Keywords:

chromosomal abnormalities

preimplantation genetic diagnosis

comparative genomic hybridizatio

Authors:

Mikitenko D.A.

GU "Institut gigieny i meditsinskoĭ kologii im. A.N. Marzeeva Natsional'noĭ akademii meditsinskikh nauk Ukrainy", Kiev, Ukraina

Pilip L.Ia.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev

Spinenko L.A.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev

Lavrova E.V.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev

Zukin V.D.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev, Ukraina

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