Dinitrosyl iron complexes with glutathione reduces the pain in rats with experimental endometriosis

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Burgova E.N.

Institut khimicheskoĭ fiziki im. N.I. Semenova RAN, Moskva

Tkachev N.A.

Inctitut ximicheckoĭ fiziki im. N.N. Cemenova RAN

Mikoian V.D.

Inctitut ximicheckoĭ fiziki im. N.N. Cemenova RAN

Stepanian A.A.

Kafedpa peppoduktivnoĭ meditsiny i xipupgii Mockovckogo univepciteta meditsiny i ctomatologii

Tsyganov A.A.

Dmitrov City Hospital, Dmitrov, Russia

Vanin A.F.

Semenov institute of chemical physics of the Russian academy of sciences, Moscow, Russia;
Institute for regenerative medicine, Sechenov First Moscow State Medical University, Moscow, Russia

Dinitrosyl iron complexes with glutathione reduces the pain in rats with experimental endometriosis

Authors:

Adamyan L.V., Burgova E.N., Tkachev N.A., Mikoian V.D., Stepanian A.A., Tsyganov A.A., Vanin A.F.

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Journal: Russian Journal of Human Reproduction. 2013;(5): 73‑80

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Adamyan LV, Burgova EN, Tkachev NA, Mikoian VD, Stepanian AA, Tsyganov AA, Vanin AF. Dinitrosyl iron complexes with glutathione reduces the pain in rats with experimental endometriosis. Russian Journal of Human Reproduction. 2013;(5):73‑80. (In Russ.)

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The effect of binuclear dinitrosyl iron complexes (DNIC) with glutathione on endometrioid tumors and painful manifestations in rats with experimental endometriosis have been studied. Two fragments of endometrium with myometrium (2×2 mm) from the left uterine horn was grafted to the inner surface of the anterior abdominal wall. The test animals received intraperitoneal injections of 0.5 ml DNIC-glutathione at the dose of 12.5 micromole per kg daily for 12 days. The injections resulted in more than a 2-fold decrease in the total volume of both large tumors formed from grafts. Painful manifestations in the experimental group significantly decreased as compared with the control group. Breach of transferrin structure was recorded in animals of the experimental and control groups. The degradation resulted in release of a high amount of nitric oxide molecules and nitrosonium ions from DNICs affecting the tumors by the way of the cytotoxic effect.

Keywords:

experimental endometriosis

dinitrosyl iron complexes with glutathion

Authors:

Adamyan L.V.

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Burgova E.N.

Institut khimicheskoĭ fiziki im. N.I. Semenova RAN, Moskva

Tkachev N.A.

Inctitut ximicheckoĭ fiziki im. N.N. Cemenova RAN

Mikoian V.D.

Inctitut ximicheckoĭ fiziki im. N.N. Cemenova RAN

Stepanian A.A.

Kafedpa peppoduktivnoĭ meditsiny i xipupgii Mockovckogo univepciteta meditsiny i ctomatologii

Tsyganov A.A.

Dmitrov City Hospital, Dmitrov, Russia

Vanin A.F.

Semenov institute of chemical physics of the Russian academy of sciences, Moscow, Russia;
Institute for regenerative medicine, Sechenov First Moscow State Medical University, Moscow, Russia

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