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Mikitenko D.A.

GU "Institut gigieny i meditsinskoĭ kologii im. A.N. Marzeeva Natsional'noĭ akademii meditsinskikh nauk Ukrainy", Kiev, Ukraina

Zukin V.D.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev, Ukraina

Effectiveness of array-comparative genomic hybridization application for preimplantation genetic testing of embryos in patients with multiple ivf failures

Authors:

Mikitenko D.A., Zukin V.D.

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Journal: Russian Journal of Human Reproduction. 2013;(5): 68‑70

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To cite this article:

Mikitenko DA, Zukin VD. Effectiveness of array-comparative genomic hybridization application for preimplantation genetic testing of embryos in patients with multiple ivf failures. Russian Journal of Human Reproduction. 2013;(5):68‑70. (In Russ.)

 
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The effectiveness of array-CGH for preimplantation screening of embryos in patients with multiple IVF failures was studied. It was shown that the selection of embryos by genetic screening allows to reach the pregnancy rate of 63.3% per transfer versus 13.3% in control group. The preimplantation genetic screening in patients with multiple IVF failures was proved to increase the efficiency of ART.

Keywords:

comparative genomic hybridization
preimplantation genetic screening
multiple IVF failure

Authors:

Mikitenko D.A.

GU "Institut gigieny i meditsinskoĭ kologii im. A.N. Marzeeva Natsional'noĭ akademii meditsinskikh nauk Ukrainy", Kiev, Ukraina

Zukin V.D.

Klinika reproduktivnoĭ meditsiny "Nadiia", Kiev, Ukraina

List of references:

  1. VanVoorhis B. Outcomes From Assisted Reproductive Technology. Obstet Gynecol 2006; 107: 1: 183-200.
  2. Zhihong Y., Liu J., Colins G.S. et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogen 2012; 5: 24: 1-8.
  3. Health and Welfare of ART Children. Ed. A.G. Sutcliffe. Abingdon: Informa Healthcare 2006.
  4. Fiorentino F., Spizzichino L., Bono S. et al. PGD for reciprocal and Robertsonian translocation using array comparative genomic hybridization. Hum Reprod 2011; 26: 7: 1925-1935.
  5. Wilton L., Voullarie L., Sargeant P. et al. Preimplantation aneuploidy screening using comparative genomic hybridization or fluorescence in situ hybridization of embryos from patients with recurrent implantation failure. Fertil Steril 2003; 80: 4: 860-868.
  6. Caglar G. S., Asimakopoulos B., Nokilletos N. et al. Preimplantation genetic diagnosis for aneuploidy screening in repeated implantation failure. RBM online 2005; 10: 3: 381-388.
  7. Yang Z., Liu J., Collins G.S. et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet 2012; 5: 2: 1-8.
  8. Munne S. Preimplantation Genetic Diagnosis for Aneuploidy and Translocations Using Array Comparative Genomic Hybridization. Curr Genom 2012; 13: 463-470.

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