CLINICAL AND MORPHOLOGICAL PECULIARITIES OF BRCA1-ASSOCIATED BREAST CANCER IN YOUNG WOMEN
D.E. Avtomonov, A.A. Parokonnaya, L.N. Lyubchenko, M.I. Nechushkin, M.B. Nurberdiyev
Young patients with breast cancer and BRCA1 gene mutation is of certain scientific interest. Differences in molecular pathogenesis between BRCA-associated and sporadic breast cancer can predetermine clinical and morphological features of both groups.
Key words: breast cancer, reproductive age, BRCA1/2 (page 15—19)
GESTAGENS EFFICACY ACCORDING TO THEIR COMPOSITION AND THE ROUTE OF ADMINISTRATION
Т.А. Nazarenko, N.А. Zyriaeva, М.U. Magamadova
The literature regarding efficacy and acceptability of different gestagen-like drugs according to their composition, the route of administration and pharmacokinetics is analyzed in this review. The advantages of micronized progesterone in the form of the vaginal gel have been demonstrated as a result of some beneficial biological effects such as adequate endometrium transformation and long-term biological defense of vaginal mucous against infectious agents due to bioadhesive polymer polycarbophil.
Key words: gestagens, progesterone, endometrium transformation, bioadhesive polymer polycarbophil, luteal phase support (page 20—25)
THE EFFECT OF CHRONIC AUTOIMMUNE LIVER DISEASE IN FEMALE RATS ON THE OFFSPRING’S SEMINIFEROUS EPITHELIUM IN THE NEONATAL PERIOD
M.L. Sizonenko, G.V. Bryuhin, E.V. Kustavinova
The results demonstrate the antenatal spermatogenesis disorders in offspring of female rats with chronic autoimmune liver disease. Decrease of the quantitative characteristics of follicular Sertoli cells supporting the germ cells was observed.
Key words: autoimmune liver disease, spermatogenesis, Sertoli cells (pаge 26—28)
THE INFLUENCE OF VAGINAL RELEASING SYSTEM NUVARING ON CARBOHYDRATE METABOLISM IN WOMEN OF REPRODUCTIVE AGE WITH DIABETES MELLITUS TYPE 1
О.R. Grigoryan, Е.N. Andreeva, I.I. Dedov
The use of hormonal releasing systems with parenteral introduction in women of reproductive age with diabetes mellitus type 1 is valuable because the optimal control of menstrual cycle, high acceptability and minimal influence on a carbohydrate metabolism.
Тhe prolonged mode of application of «NovaRing» is simply and reduces probability of missing daily dose, therefore many women consider it more convenient, than oral contraceptives. This method allows to hide the use of contraception that can be attractive for some patients.
Key words: hormonal vaginal releasing system, diabetes mellitus type 1, extended regimen (page 29—36)
FEMALE REPRODUCTIVE SYSTEM AFTER THE TREATMENT OF POSTCRANIAL FOSSA TUMORS AND LEUKEMIA IN CHILDHOOD
E.E. Gubernatorova, M.G. Pavlova, T.V. Kaznacheeva, G.A. Melnichenko , N.A. Mazerkina, Y.P. Sych, O.G. Zheludcova, V.D. Tenedieva
The treatment of postcranial fossa tumors and leukemia in childhood can affect reproductive system. Cranial irradiation may cause gonadotrophin deficiency while chemotherapy and spinal irradiation may lead to primary hypogonadism. Reproductive status of 32 female postcranial fossa tumors and leukemia survivals was assessed. Results of the study demonstrated the high prevalence of primary hypogonadism after the treatment. The signs of diminished ovarian reserve in this cohort of patients were found.
Key words: postcranial fossa tumors, leukemia, chemotherapy, spinal irradiation, hypogonadism, diminished ovarian reserve (page 37—41)
THE ROLE OF BIOGENIC AMINES IN THE DEVELOPMENT OF METABOLIC DISORDERS AFTER HYSTERECTOMY
N.M. Podzolkova, V.I. Podzolkov, T.I. Nikitina, A.E. Bragina, O.L. Glazkova
The study included 268 women after hysterectomy with climacteric syndrome. First group consisted of 126 women after hysterectomy, the second group included 142 women after hysterectomy and unilateral adnexectomy. 25 patients with small asymptomatic uterine fibroid formed the control group. Hysterectomy was found to be a risk factor of arterial hypertension and diabetes mellitus type 2. BMI was significantly higher in second group compared with first and control groups. Dyslipidemia was found in 15,1%, 26,8 and 8% in group1, group 2 and control group respectively. The prolactin, histamine, serotonine and 5-oxyindol acetic acid concentrations after hysterectomy were significantly higher compared with control group.
Key words: hysterectomy, surgical climacteric syndrome, metabolic disorders, biogenic amins (page 42—47)
PROSPECTS AND FIRST RESULTS OF AUTOLOGOUS TRANSPLANTATION OF OVARIAN TISSUE
N.N. Rukhlyada, N.O. Motovilova, A.Yu. Gryaznov, E.I. Biryukovа, D.M. Gasimova, M.A. Melnikova
In the article the indications for autologous transplantation of ovarian tissue, as well as a comparative analysis of methods of cryopreservation of ovarian tissue and the prospects of this method of preserving ovarian reserve. Is a case report indicating the results of the author's technique autologous ovarian tissue.
Key words: autotransplantation of ovarian tissue, cryopreservation of ovarian tissue, ovarian reserve (page 48—51)
TUBAL FACTOR INFERTILITY: CLINICAL ANALYSIS OF IVF SUCCESS and FAILURE
A.S. Onishchenko, V.A. Burlev, N.A. Ilyasova, L.N. Kuzmichev
Analysis of IVF protocol efficiency in 46 patients with tubal infertility was performed. The pregnancy rate was 41.4%. In the group with concomitant gynecologic pathology (endometriosis, uterus fibroid) the pregnancy rate was 17,6%. The tubal infertility was shown to be caused by angiogenic and inflammatory stress.
Key words: tubal infertility, IVF, inflammation (page 56—61)
REGNANCY AFTER ICSI into OOCYTE without ZONA PELLUCIDA (A CASE REPORT)
М.P. Petrushko, V.I. Pinyaev, V.V. Podufaly, S.S. Pravdina, N.N. Chub
The clinical case of pregnancy after ICSI of epididymal cryopreserved spermatozoa into zona-free oocyte is presented. The peculiarities and results of working with oocytes without zona pellucida are discussed.
Key words: oocyte, zona pellucida, epididymal spermatozoa, ICSI (page 62—64)
EMPTY FOLLICLE SYNDROME IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS (A REVIEW)
V.S. Samulyzhko, I.U. Kogan
A review of literature concerning empty follicle syndrome (EFS) is devoted to the most controversial issues of possible etiology, pathogenesis, diagnostics, prediction and management of the syndrome.
Key words: infertility, IVF, empty follicle syndrome (page 65—69)
THE RIGHTS OF HIV-DISCORDANT COUPLES IN ASSISTED REPRODUCTIVE TECHNOLOGIES
Yu.A. Solovieva, A.V. Korneev
HIV-discordant couples in most medical institutions of Russia are turned to the use of assisted reproductive technologies. Organization of work with HIV-discordant couples is described. The relative safety of ART using semen of HIV-infected husband is demonstrated. The informed consent to IVF or artificial insemination with sperm of HIV-infected-consistent husband was developed and presented.
Key words: discordant couples, HIV, IVF, artificial insemination (page 70—73 )
THE DIAGNOSTIC SYSTEM DEVELOPMENT FOR THE DETECTION OF AZF-MICRODELETIONS WITH MULTIPLEX REAL-TIME PCR
A.S. Weiner, U.A. Boyarskikh, E.N. Voronina, A.N. Shirshova, O.V. Mishukova, L.V. Osadchuk, M.L. Filipenko
Microdeletions of AZFa, AZFb and AZFc regions on the long arm of the Y-chromosome cause azoo- and oligozoospermia. We developed the diagnostic system for detection of these microdeletions with the help of two tetraplex real-time polymerase chain reactions.
Key words: male infertility, AZF region, PCR, TaqMan, diagnostic system (page 74—77)
PARTICIPATION OF NF-KB FACTOR AND ITS REGULATORY PROTEINS IN THE DEVELOPMENT OF COMPLICATED PREGNANCY
V.O. Gunko, T.N. Pogorelova, V.A. Linde
The activity of p65 subunit of transcriptional factor NF-kB during physiological and complicated pregnancy was investigated. The decrease of NF-kB activity during fetal growth retardation and preeclampsia was observed. The correlation with the disorders of the activity regulators expression was demonstrated. The possible mechanisms of the revealed disorders and their role in the development of complicated pregnancy are discussed.
Key words: transcriptional factor NF-kB, pregnancy, amniotic fluid, proteins (page 87—90)
THE USE OF MODERN LACTOBACILLUS STRAINS IN THE BACTERIAL VAGINOSIS TREATMENT IN PREMENOPAUSAL WOMEN
S.А. Levakov, А.G. Kedrova, N.N. Chelnokova
Women with bacterial vaginosis (n=100) diagnosed by standard criteria were treated with three strains of Lactobacillus. The characteristics of vaginal flora were investigated. The comparison of two groups (lactobacilli group and placebo group) regarding the «time from cure to relapse» showed statistically significant benefits in favor of the lactobacilli treatment in premenopuse women with recurrent bacterial vaginosis.
Key words: bacterial vaginosis, treatment, probiotics, Lactobacillus (page 91—95)
THE CELL AND HUMORAL IMMUNITY IN PREMENOPAUSAL WOMEN WITH ENDOMETRIAL HYPERPLASIA
L.V. Saprykina, Yu.E. Dobrokhotova, O.A. Saprykina, V.I. Peshkin
The results of the immune status investigation in premenopausal patients with endometrial hyperplasia are presented. The association of immune disorders with hyperestrogenemia in these patients was demonstrated.
Key words: endometrial hyperplasia, cell immunity, humoral immunity (page 95—98 )