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Mokrysheva N.G.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Krupinova Yu.A.

Endocrinology Research Centre, Moscow, Russia

Dolgushin M.B.

Blokhin Russian Cancer Research Center, Moscow, Russia

Odzharova A.A.

Blokhin Russian Cancer Research Center, Moscow, Russia

Voronkova I.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Voskoboĭnikov V.V.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Kuznetsov N.S.

Endocrinology Research Centrer

Positron emission tomography in combination with computed tomography with 18F-fluorocholine in the topical diagnosis of parathyroid tumors and secondary changes in bone tissue associated with hyperparathyroid osteodystrophy: two case studies

Authors:

Mokrysheva N.G., Krupinova Yu.A., Dolgushin M.B., Odzharova A.A., Voronkova I.A., Voskoboĭnikov V.V., Kuznetsov N.S.

More about the authors

Journal: Problems of Endocrinology. 2018;64(5): 299‑305

DOI: 10.14341/probl9548

Views: 2396

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Table of contents

POSITRON EMISSION TOMOGRAPHY IN COMBINATION WITH COMPUTED TOMOGRAPHY WITH 18F-FLUOROCHOLINE IN THE TOPICAL DIAGNOSIS OF PARATHYROID TUMORS AND SECONDARY CHANGES IN BONE TISSUE ASSOCIATED WITH HYPERPARATHYROID OSTEODYSTROPHY: TWO CASE STUDIES
POSITRON EMISSION TOMOGRAPHY IN COMBINATION WITH COMPUTED TOMOGRAPHY WITH 18F-FLUOROCHOLINE IN THE TOPICAL DIAGNOSIS OF PARATHYROID TUMORS AND SECONDARY CHANGES IN BONE TISSUE ASSOCIATED WITH HYPERPARATHYROID OSTEODYSTROPHY: TWO CASE STUDIES

To cite this article:

Mokrysheva NG, Krupinova YuA, Dolgushin MB, Odzharova AA, Voronkova IA, Voskoboĭnikov VV, Kuznetsov NS. Positron emission tomography in combination with computed tomography with 18F-fluorocholine in the topical diagnosis of parathyroid tumors and secondary changes in bone tissue associated with hyperparathyroid osteodystrophy: two case studies. Problems of Endocrinology. 2018;64(5):299‑305. (In Russ.)
https://doi.org/10.14341/probl9548

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Primary hyperparathyroidism (PHPT) is caused by parathyroid malignant neoplasm in 1% of cases. The risk of the latter is higher in patients with symptomatic PHPT. The prognosis in this group of patients depends on the extent of the process and primary surgical intervention. In these cases, the differential diagnosis between secondary foci in the bones associated with parathyroid cancer and hyperparathyroid osteodystrophy is a challenging problem. This article describes two cases of severe PHPT accompanied by hyperparathyroid osteodystrophy suspected for metastatic parathyroid cancer. Positron emission tomography in combination with computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) and/or 18F-fluorocholine was included in the examination algorithm. In both cases, pronounced bone changes similar to parathyroid metastases were observed. Accumulation of 18F-fluorocholine was also observed only in altered parathyroid gland. Histological examination of postoperative material verified benign parathyroid tumors, and characteristic lesions of bone tissue were regarded as areas of osteodystrophy. Therefore, accumulation of 18F-fluorocholine at the areas of bone destruction does not enable differentiation between hyperparathyroid osteodystrophy and metastatic lesions; further research is required to assess sensitivity and specificity of the method with respect to topical diagnosis of altered parathyroid gland.

Keywords:

primary hyperparathyroidism
positron emission tomography
hyperparathyroid osteodystrophy
parathyroid cancer
clinical case

Authors:

Mokrysheva N.G.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Krupinova Yu.A.

Endocrinology Research Centre, Moscow, Russia

Dolgushin M.B.

Blokhin Russian Cancer Research Center, Moscow, Russia

Odzharova A.A.

Blokhin Russian Cancer Research Center, Moscow, Russia

Voronkova I.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Voskoboĭnikov V.V.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Kuznetsov N.S.

Endocrinology Research Centrer

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