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Kudinov V.I.

Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Nichitenko M.S.

Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Ibragimova V.A.

Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Clinical benefits of switching type 2 diabetes patients from human insulins to insulin analogs

Authors:

Kudinov V.I., Nichitenko M.S., Ibragimova V.A.

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Journal: Problems of Endocrinology. 2013;59(6): 77‑79

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To cite this article:

Kudinov VI, Nichitenko MS, Ibragimova VA. Clinical benefits of switching type 2 diabetes patients from human insulins to insulin analogs. Problems of Endocrinology. 2013;59(6):77‑79. (In Russ.)

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Achievement and long-term maintenance of optimal glucose control is still a big problem in many patients with type 2 diabetes. Diabetes related complications and cardiovascular diseases also can do more difficult the choice of glucose lowering therapy. Insulin therapy is the most effective method of treatment in such patients. However treatment with human insulin is often associated with hypoglycemia and weight gain, which are additional barriers to achieve glycemic control. Presented clinical cases show that switching from human insulin for insulin analogues detemir (Levemir) and aspart (NovoRapid) provide a significant improvement in glycemic control without increasing of risk of hypoglycemia and weight gain.

Keywords:

type 2 diabetes mellitus
hypoglycemia
insulin analogues
Levemir
NovoRapid

Authors:

Kudinov V.I.

Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Nichitenko M.S.

Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Ibragimova V.A.

Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

List of references:

  1. Kudinov V.I., Nichitenko M.S. Sravnitel'naya otsenka effektivnosti razlichnykh skhem insulinoterapii u bol'nykh sakharnym diabetom 2-go tipa i ishemicheskoi bolezn'yu serdtsa. Sakharnyi diabet 2012; 2: 23-27.
  2. Fuchtenbusch M., Hummel M. Intensive blood sugar treatment in type 2 diabetics: no evidence for increased mortality in the ADVANCE study compared with ACCORD study. MMW Fortschr Med 2008; 150: 17: 42-44.
  3. Anderson J.H. Jr, Brunelle R.L., Koivisto V.A., Pfützner A., Trautmann M.E., Vignati L., DiMarchi R. Reduction of postprandial hyper-glycemia and frequency of hypoglycemia in IDDM patients on insulin-analog treatment. Diabetes 1997; 46: 265-270.
  4. Hirsch I. Insulin analogues. N Engl J Med 2005; 352: 174-183.

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