The comparative analysis of the results of clinical and hormonal investigations in the patients presenting with ACTH-producing neuroendocrine tumours

Marova E.I.

Endocrinology Research Centrer

Arapova S.D.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Kolesnikova G.S.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Sitkin I.I.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossii, Moskva

Goncharov N.P.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

The comparative analysis of the results of clinical and hormonal investigations in the patients presenting with ACTH-producing neuroendocrine tumours

Authors:

Marova E.I., Arapova S.D., Kolesnikova G.S., Sitkin I.I., Goncharov N.P.

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Journal: Problems of Endocrinology. 2013;59(4): 11‑17

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Marova EI, Arapova SD, Kolesnikova GS, Sitkin II, Goncharov NP. The comparative analysis of the results of clinical and hormonal investigations in the patients presenting with ACTH-producing neuroendocrine tumours. Problems of Endocrinology. 2013;59(4):11‑17. (In Russ.)

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This study included the patients presenting with neuroendocrine tumours (NET) and the clinical picture of hypercoticism caused by excessive ACTH secretion from the tumour. The overwhelming majority of the patients (85%) suffered Cushing's disease (CD) associated with a pituitary tumour. The remaining 15% of the patients presented with ACTH-ectopic syndrome (ACTH-ES). The clinical picture of CD and ACTH-ES was very similar. The latter condition was associated with the higher plasma ACTH and cortisol levels as well as the free cortisol content in 24 hour urine and saliva samples collected in the evening compared with CD even though the differences were insignificant due to data scattering. Decompressin administration and catheterization of inferior petrosal sinuses caused a much greater enhancement of the ACTH level in the patients with CS in comparison with those suffering ASTH-ES.

Keywords:

ACTH-ectopic syndrome

Cushing's disease

ACTH

cortisol in biological fluids

selective blood sampling from inferior petrosal sinuses

Authors:

Marova E.I.

Endocrinology Research Centrer

Arapova S.D.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Kolesnikova G.S.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Sitkin I.I.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossii, Moskva

Goncharov N.P.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

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