The application of the ACTH (5 mcg) test for diagnostics of the non-classical form of congenital adrenal hyperplasia (results of a study)

Chagaĭ N.B.; Fadeev V.V.; Prokof'ev S.A.; Ivanova O.N.; Smirnova N.B.; Atamanova T.M.; Tishina Iu.V.

doi:https://doi.org/

Chagaĭ N.B.

Tsentr planirovaniia sem'i i reproduktsii Kraevogo klinicheskogo diagnosticheskogo tsentra, Stavropol'

Fadeev V.V.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Prokof'ev S.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Ivanova O.N.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Smirnova N.B.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Atamanova T.M.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Tishina Iu.V.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

The application of the ACTH (5 mcg) test for diagnostics of the non-classical form of congenital adrenal hyperplasia (results of a study)

Authors:

Chagaĭ N.B., Fadeev V.V., Prokof'ev S.A., Ivanova O.N., Smirnova N.B., Atamanova T.M., Tishina Iu.V.

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Journal: Problems of Endocrinology. 2013;59(2): 34‑39

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To cite this article:

Chagaĭ NB, Fadeev VV, Prokof'ev SA, Ivanova ON, Smirnova NB, Atamanova TM, Tishina IuV. The application of the ACTH (5 mcg) test for diagnostics of the non-classical form of congenital adrenal hyperplasia (results of a study). Problems of Endocrinology. 2013;59(2):34‑39. (In Russ.)

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Abstract:

This study has demonstrated high sensitivity and specificity of the low-dose (5 mcg) 1-24-ACTH stimulation test used for diagnostics of the non-classical form of congenital adrenal hyperplasia (21-hydroxilase deficiency).

Keywords:

non-classical form of congenital adrenal hyperplasia

low-dose test

ACTH

Authors:

Chagaĭ N.B.

Tsentr planirovaniia sem'i i reproduktsii Kraevogo klinicheskogo diagnosticheskogo tsentra, Stavropol'

Fadeev V.V.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Prokof'ev S.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Ivanova O.N.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Smirnova N.B.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Atamanova T.M.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Tishina Iu.V.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

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References:

Dedov I.I., Fadeev V.V., Mel'nichenko G.A. Nedostatochnost' nadpochechnikov. M: Znanie 2002; 203-218.
Unlühizarci K., Keleєtimur F., Güven M., Bayram F., Colak R. The value of low dose (1 microg) ACTH stimulation test in the investigation of non-classic adrenal hyperplasia due to 11beta-hydroxylase deficiency. Exp Clin Endocrinol Diabet 2002; 110: 8: 381-385.
Panamonta O., Thinkhamrop B., Kirdpon W., Pudtawaro L.O., Sungsahachart D. Adrenocorticotropin stimulation test in congenital adrenal hyperplasia: comparison between standard and low dose test. J Med Ass Thai 2003; 86: 7: 634-640.
Chagai N.B., Fadeev V.V., Bakulina E.G. Nizkodozirovannyi test s AKTG v diagnostike neklassicheskoi formy vrozhdennoi disfunktsii kory nadpochechnikov. Probl endokrinol 2010; 2: 10-14.
http://www.issam.ch/freetesto.htm
Lee H., Chang J., Tsai C., Tsai F., Chao H., Chung B. Analysis of the chimeric CYP21 P/CYP 21 gene in steroid 21-hydroxylase deficiency. Clin Chem 2000; 46: 5: 606-611.
Wedell A., Luthman H. Steroid 21-hydroxylase deficiency: two additional mutations in salt-wasting disease and rapid screening of disease-causing mutations. Human Mol Genet 1993; 2: 5: 499-504.
New M.I. Nonclassical 21-Hydroxylase Deficiency. J Clin Endocrinol Metabol 2006; 91: 11: 4205-4214.
Moran C. Nonclassic adrenal hyperplasia. Fertil Steril 2006; 86: Suppl 1: S3.
Schindhelm R.K., van de Leur J.J., Rondeel J.M. Salivary cortisol as an alternative for serum cortisol in the low-dose adrenocorticotropic hormone stimulation test? J Endocrinol Invest 2010; 33: 2: 92-95.
Simůnková K., Hampl R., Hill M., Doucha J., Stárka L., Vondra K. Salivary cortisol in low dose (1 microg) ACTH test in healthy women: comparison with serum cortisol. Physiol Res 2007; 56: 4: 449-453.
White P.C., Speiser P.W. Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Endocrin Rew 2000; 21: 3: 245-291.
L'Allemand D., Tardy V., Grüters A., Schnabel D., Krude H., Morel Y. How a patient homozygous for a 30-kb deletion of the C4-CYP 21 genomic region can have a nonclassic form of 21-hydroxylase deficiency. J Clin Endocrinol Metabol 2000; 85: 12: 4562-4567.
Wedell A., Luthman H. Steroid 21-hydroxylase deficiency: two additional mutations in salt-wasting disease and rapid screening of disease-causing mutations. Hum Mol Genet 1993; 2: 5: 499-504.