Synthesis of new exenatide analogs and investigation of their influence on glycemia and renal function in rats

Bogolepova A.E.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Kutina A.V.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Marina A.S.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Nikol'skaia S.K.

Sankt-Peterburgskiĭ gosudarstvennyĭ universitet

Shakhmatova E.I.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Titov M.I.

Sankt-Peterburgskiĭ gosudarstvennyĭ universitet

Natochin Iu.V.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Synthesis of new exenatide analogs and investigation of their influence on glycemia and renal function in rats

Authors:

Bogolepova A.E., Kutina A.V., Marina A.S., Nikol'skaia S.K., Shakhmatova E.I., Titov M.I., Natochin Iu.V.

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Journal: Problems of Endocrinology. 2011;57(3): 42‑47

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Bogolepova AE, Kutina AV, Marina AS, Nikol'skaia SK, Shakhmatova EI, Titov MI, Natochin IuV. Synthesis of new exenatide analogs and investigation of their influence on glycemia and renal function in rats. Problems of Endocrinology. 2011;57(3):42‑47. (In Russ.)

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New analogs of exenatide with amino acid substitutions at 14, 35, and 39 have been synthesized. They were shown to be more stable than original exenatide in aqueous solutions. In vivo testing on rat models of glucose loading showed that exenatide and its novel analogs possess hypoglycemic activity and stimulate renal excretion of sodium and magnesium ions and osmotically free water but have virtually no effect on the elimination of potassium ions. Experiments with isolated skin and urinary bladder preparations from male frogs showed that exenatide and its analogs promote biosynthesis of physiologically active compounds modulating renal functions.

Keywords:

exenatide

exenatide analogs

synthesis

hypoglycemic activity

kidney

effects of newly synthesized exenatide analogs

Authors:

Bogolepova A.E.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Kutina A.V.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Marina A.S.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Nikol'skaia S.K.

Sankt-Peterburgskiĭ gosudarstvennyĭ universitet

Shakhmatova E.I.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Titov M.I.

Sankt-Peterburgskiĭ gosudarstvennyĭ universitet

Natochin Iu.V.

Institut évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

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