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Molitvoslovova N.N.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Acromegaly: recent progress in diagnostics and treatment

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Molitvoslovova N.N.

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Journal: Problems of Endocrinology. 2011;57(1): 46‑59

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ACROMEGALY: RECENT PROGRESS IN DIAGNOSTICS AND TREATMENT
ACROMEGALY: RECENT PROGRESS IN DIAGNOSTICS AND TREATMENT

To cite this article:

Molitvoslovova NN. Acromegaly: recent progress in diagnostics and treatment. Problems of Endocrinology. 2011;57(1):46‑59. (In Russ.)

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Acromegaly is a serious disease with different complications leads to reduced life expectancy and increase mortality. Only early diagnosis and modern methods of management of disease lead to remission. According to consensus on criteria for cure of acromegaly (2010) the measurement of GH and age-matched total IGF-I concentrations are the most important biochemical variables for the diagnosis of acromegaly and for monitoring progression or treatment response. The optimal disease control is now defined as IGF-I level in the age – adjusted normal range, random GH levels less than 1,0 µg/liter and nadir GH level during OGTT less than 0,4 µg/liter. MRI with use a contract substance is the best method of adenoma visualization. The trassphenoidal surgery with new technologies (endoscope, intraoperative blood sampling, neuronavigation, intraoperative MRI), radiosurgery, modern medical treatment (multiligand long-acting somatostatin analogs, GH receptor antagonist) are effective modalities for treatment of acromegaly, which elaborated last decades.

Keywords:

acromegaly
methods of diagnosis
transsphenoidal adenomectomy
medical treatment

Authors:

Molitvoslovova N.N.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

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