Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system

Abduvaliev A.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Ismaĭilova M.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Gil'dieva M.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Saatov T.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system

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Abduvaliev A.A., Ismaĭilova M.A., Gil'dieva M.S., Saatov T.S.

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Journal: Problems of Endocrinology. 2010;56(3): 31‑33

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Abduvaliev AA, Ismaĭilova MA, Gil'dieva MS, Saatov TS. Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system. Problems of Endocrinology. 2010;56(3):31‑33. (In Russ.)

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It is shown that combined treatment with thyroxin and diazepam permits to avoid negative effect of either drug on the bone tissue. Mutual regulation of thyroxin and diazepam activities is mediated through their competitive binding to common receptors. It is hypothesized that the key factor in this process is steric availability of the receptor; in other words, close localization of thyroxin and diazepam targets may interfere with simultaneous activation of receptors by the two ligands and account for the effects of their combined administration described in the present work.

Keywords:

thyroxin

diazepam

neutron activation analysis

bone tissue

model carcinogenic system

Authors:

Abduvaliev A.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Ismaĭilova M.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Gil'dieva M.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Saatov T.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

List of references:

Martin J.V., Padron J.M., Newman M.A. et al. Inhibition of the activity of the native gamma-aminobutyric acid A receptor by metabolites of thyroid hormones: correlations with molecular modeling studies. Brain Res 2004;1004:1-2:98-107.
Zamoner A., Funchal C., Heimfarth L. et al. Short-term effects of thyroid hormones on cytoskeletal proteins are mediated by GABAergic mechanisms in slices of cerebral cortex from young rats. Cell Mol Neurobiol 2006;26:2:209-224.
Ortiz-Butron R., Pacheco-Rosado J., Hernández-Garcia A. et al. Mild thyroid hormones deficiency modifies benzodiazepine and mu-opioid receptor binding in rats. Neuropharmacology 2003;44:1:111-116.
Srompton M., Virj S., Doyle V. et al. The mitochondrial permeability transition pore. Biochem Soc Symp 1999;66:167-171.
Abduvaliev A.A., Gil'dieva M.S., Saatov T.S. Tiroksinovaya regulyatsiya proliferatsii estrogen- i progesteronotritsatel'nykh kletok raka molochnoi zhelezy. Ros onkol zhurn 2006;2:15-18.
Abduvaliev A.A., Gil'dieva M.S., Saatov T.S. Biologicheskie effekty tiroksina v eksperimental'nom kantserogeneze. Probl endokrinol 2005;1:46-49.
Burggraaf J., Tulen J.H., Lalezari S. et al. Sympathovagal imbalance in hyperthyroidism. Am J Physiol Endocrinol Metab 2001;281:1:190-195.
Kowalczyk P., Sielańczyk A., Nowak J. Effects of L-thyroxine suppressive therapy on cardiac mass in patients with differentiated thyroid cancer. Pol Arch Med Wewn 2001;105:123-127.
Bruyere O., Delferriere D., Roux C. Effects of strontium ranelat on spinal osteoarthritis progression. Ann Rheum Dis 2008;67:335-339.

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