Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system

Abduvaliev A.A.; Ismaĭilova M.A.; Gil'dieva M.S.; Saatov T.S.

doi:https://doi.org/

Abduvaliev A.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Ismaĭilova M.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Gil'dieva M.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Saatov T.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system

Authors:

Abduvaliev A.A., Ismaĭilova M.A., Gil'dieva M.S., Saatov T.S.

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Journal: Problems of Endocrinology. 2010;56(3): 31‑33

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To cite this article:

Abduvaliev AA, Ismaĭilova MA, Gil'dieva MS, Saatov TS. Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system. Problems of Endocrinology. 2010;56(3):31‑33. (In Russ.)

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Abstract:

It is shown that combined treatment with thyroxin and diazepam permits to avoid negative effect of either drug on the bone tissue. Mutual regulation of thyroxin and diazepam activities is mediated through their competitive binding to common receptors. It is hypothesized that the key factor in this process is steric availability of the receptor; in other words, close localization of thyroxin and diazepam targets may interfere with simultaneous activation of receptors by the two ligands and account for the effects of their combined administration described in the present work.

Keywords:

thyroxin

diazepam

neutron activation analysis

bone tissue

model carcinogenic system

Authors:

Abduvaliev A.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Ismaĭilova M.A.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Gil'dieva M.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

Saatov T.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

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