The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Troshina E.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Bel'tsevich D.G.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Molashenko N.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Gazizova D.O.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Diagnosis, differential diagnosis, and treatment of endogenous hypercorticism

Authors:

Troshina E.A., Bel'tsevich D.G., Molashenko N.V., Gazizova D.O.

More about the authors

Journal: Problems of Endocrinology. 2010;56(2): 53‑63

Read: 41360 times

Download PDF (RU)
Contact the author
Table of contents

DIAGNOSIS, DIFFERENTIAL DIAGNOSIS, AND TREATMENT OF ENDOGENOUS HYPERCORTICISM
DIAGNOSIS, DIFFERENTIAL DIAGNOSIS, AND TREATMENT OF ENDOGENOUS HYPERCORTICISM

To cite this article:

Troshina EA, Bel'tsevich DG, Molashenko NV, Gazizova DO. Diagnosis, differential diagnosis, and treatment of endogenous hypercorticism. Problems of Endocrinology. 2010;56(2):53‑63. (In Russ.)

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

The present review deals with diagnosis, differential diagnosis, and treatment of endogenous hypercorticism. Key diagnostic steps are described along with main pharmacological tests, instrumental methods, treatment and follow-up strategies.

Keywords:

Cushing's syndrome
corticosteroma
subсlinical Cushing's syndrome

Authors:

Troshina E.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Bel'tsevich D.G.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Molashenko N.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Gazizova D.O.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Close metadata

References:

  1. Marova E.I., Belyaeva A.V., Ilovaiskaya I.A. Rol' ektopirovannykh retseptorov kory nadpochechnikov v patogeneze AKTG-nezavisimogo sindroma Kushinga. Probl endokrinol 2008; 1: 54: 40-45.
  2. Cavagnini F., Pecori Giraldi F. Adrenal Causes of Hypercortisolism, Endocrinology. 5-th ed 2006; 2: 2353-2378.
  3. Bertagna X., Orth D.N. Clinical and laboratory findings and results of therapy in 58 patients with adrenocortical tumors admitted to a single medical center (1951 to 1978). Am J Med 1981; 71: 855-875.
  4. Dedov I.I., Mel'nichenko G.A. Ratsional'naya farmakoterapiya zabolevanii endokrinnoi sistemy i narushenii obmena veshchestv. M: Litterra 2006; 488-510.
  5. Marova E.I., Arapova S.D., Bel'chenko L.V. Bolezn' Itsenko-Kushinga. Metod posob dlya vrachei. M 2000.
  6. Mel'nichenko G.A., Marova E.I., Dzeranova L.K. i dr. Diagnostika i lechenie neiroendokrinnykh zabolevanii. Metod posob dlya vrachei. M 2003; 3-16.
  7. Nieman L.K., Biller B.M.K., Findling J.W. et al. The Diagnosis of Cushing's Syndrome. An Endocrine Society Clin Pract Guideline J Clin Endocrinol & Metabol 2008; 93: 5: 1526-1540.
  8. Kaye T.B., Crapo L. The Cushing Syndrome: An Update on Diagnostic Tests. Ann Intern Med 1990; 112: 6: 434-444.
  9. Raff H., Findling J.W. A Physiologic Approach to Diagnosis of the Cushing Syndrome. Ann Intern Med 2003; 138; 12: 980-991.
  10. Wood P.J., Barth J.H., Freedman D.B. et al. Evidence for the low dose dexamethasone suppression test to screen for Cushing's syndrome - recommendations for a protocol for biochemistry laboratories. Ann Clin Biochem 1997; 34: Pt 3: 222-229.
  11. Goncharov N.P., Katsiya G.V., Marova E.I. i dr. Ispol'zovanie ul'trachuvstvitel'nogo metoda opredeleniya biologicheski aktivnogo svobodnogo kortizola v slyune dlya otsenki glyukokortikoidnoi funktsii kory nadpochechnikov. Probl endokrinol 2008; 3: 27-35.
  12. Liu H., Bravata D.M., Cabaccan J., Raff H., Ryzen E. Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans. Clin Endocrinol (Oxford) 2005; 63:642-649.
  13. Morris D.G., Grossman A.B., Nieman L.K. Cushing's syndrome, 5th ed. Endocrinology 2006; 1: 429-453.
  14. Invitti C., Pecori Giraldi F., De Martin M. et al. Diagnosis and management of Cushing's syndrome: Results of an Italian Multicenter study. J Clin Endocrinol Metab 1999; 84: 440-448.
  15. Kirk J.M.W., Brain C.E., Carson D.J. et al. Cushing's syndrome caused by nodular adrenal hyperplasia in children with McCune-Albright syndrome. J Pediat 1999; 134: 789-792.
  16. Klose M., Kofoed-Enevoldsen A., Ostergaard Kristensen L. Single determination of plasma ACTH using an immunoradiometric assay with high detectability differentiates between ACTH-dependent and independent Cushing's syndrome. Scand J Clin Lab Invest 2002; 62: 33-38.
  17. Law A., Hague W.M., Daly J.G. et al. Inappropriate ACTH concentrations in two patients with functioning adrenocortical carcinoma. Clin Endocrinol 1988; 29: 53-62.
  18. Slyper A.H., Finding J.W. Use of a two-site immunoradiometric assay to resolve a factitious elevation of ACTH in primary pigmented nodular adrenocortical disease. J Ped Endocrinol 1994; 7: 61-63.
  19. Komanicky P., Spark R.F., Melby J.C. Treatment of Cushing's syndrome with trilostane (WIN 24, 540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab 1978; 47: 1042-1051.
  20. Aron D.C., Raff H., Findling J.W. Effectiveness versus efficacy: The limited value in clinical practice of high dose dexamethasone suppression testing in the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 1997; 82: 1780-1785.
  21. Yanovski J.A., Cutler Jr G.B., Doppman J.L. et al. The limited ability of inferior petrosal sinus sampling with corticotropin-releasing hormone to distinguish Cushing's disease from pseudo-Cushing states or normal physiology. J Clin Endocrinol Metab 1993; 77: 503-509.
  22. Grossman A.B., Howlett T.A., Perry L. et al. CRH in differential diagnosis of Cushing's syndrome: A comparison with the dexamethasone suppression test. Clin Endocrinol (Oxford) 1988; 29: 167-178.
  23. Nieman L.K., Chrousos G.P., Oldfield E.H. et al. The ovine corticotrophin-releasing hormone stimulation test and the dexamethasone suppression test in the differential diagnosis of Cushing's syndrome. Ann Intern Med 1986; 105: 862-867.
  24. Pecori Giraldi F., Pivonello R., Ambrogio A.G. et al. The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. Clin Endocrinol (Oxford) 2007; 66: 251-257.
  25. Tsagarakis S., Vassiliadi D., Thalassinos N. Endogenous subclinical hypercortisolism: diagnostic uncertainties and clinical implications. J Endocrinol Invest 2006; 29: 471-482.
  26. Korbonits M., Bustin S.A., Kojima M. et al. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 2001; 86: 881-887.
  27. Newell-Price J., Perry L., Medbak S. et al. A combined test using desmopressin and corticotrophin-releasing hormone in the differential diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 1997; 82: 176-181.
  28. Tsagarakis S., Tsigos C., Vasiliou V. et al. The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing's syndrome: Constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretion. J Clin Endocrinol Metab 2002; 87: 1646-1653.
  29. Dedov I.I., Sitkin I.I., Belaya Zh.E. i dr. Znachenie metoda selektivnogo zabora krovi iz nizhnikh kamenistykh sinusov v differentsial'noi diagnostike AKTG-zavisimogo giperkortitsizma. Probl endokrinol 2009; 6: 32-35.
  30. Reincke M. et al. Adrenal incidentalomas: a manifestation of the metabolic syndrome Endocr Res 1996; 22: 4: 757-761.
  31. Rossi R., Tauchmanova L., Luciano A. et al. Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features. J Clin Endocrinol Metab 2000; 85: 1440-1148.
  32. Terzolo M. et al. Subclinical Cushing's Syndrome. Pituitary 2004; 7: 4: 217-223.
  33. Reincke M. et al. Subclinical Cushing's syndrome. Endocrinol Metab Clin North Am 2000; 29: 1: 43-56.
  34. Reincke M. et al. Preclinical Cushing's syndrome in adrenal «incidentalomas»: comparison with adrenal Cushing's syndrome. J Clin Endocrinol Metab 1992; 75: 3: 826-832.
  35. Torlontano M. et al. Pre-Cushing's syndrome not recognized by conventional dexamethasone suppression-tests in an adrenal «incidentaloma» patient. J Endocrinol Invest 1997; 20: 8: 501-504.
  36. Valli N. et al. Biochemical screening for subclinical cortisol-secreting adenomas amongst adrenal incidentalomas. Eur J Endocrinol 2001; 144: 401-408.
  37. Allolio B., Fassnacht M. Adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 2006; 91: 2027-2037.
  38. Arnaldi G. et al. Adrenal incidentaloma. Braz J Med Biol Res 2000; 33: 10: 1177-1189.
  39. Huiras C.M., Pehling G.B., Caplan R.H. Adrenal insufficiency after operative removal of apparently nonfunctioning adrenal adenomas. JAMA 1989; 261: 6: 894-898.
  40. Terzolo M. et al. Prevalence of adrenal carcinoma among incidentally discovered adrenal masses. A retrospective study from 1989 to 1994. Gruppo Piemontese Incidentalomi Surrenalici. Arch Surg 1997; 132: 8: 914-919.
  41. Ilias I., Chang R., Pacak K. et al. Jugular venous sampling: An alternative to petrosal sinus sampling for the diagnostic evaluation of adrenocorticotropic hormone-dependent Cushing syndrome. J Clin Endocrinol Metabol 2004; 89: 3795-3800.
  42. Bourdeau I., Bard C., Noel B. et al. Loss of brain volume in endogenous Cushing's syndrome and its reversibility after correction of hypercortisolism. J Clin Endocrinol Metab 2002; 87: 1949-1954.
  43. Hermus A.R., Smals A.G., Swinkels L.M. et al. Bone mineral density and bone turnover before and after surgical cure of Cushing's syndrome. J Clin Endocrinol Metab 1995; 80: 2859-2865.
  44. Lindsay J.R., Nansel T., Baid S. et al. Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission. J Clin Endocrinol Metab 2006; 91: 447-453.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.