Metabolic and hemostatic characteristics of patients with type 2 diabetes mellitus differing in the severity of angiopathy

Petrik G.G.; Pavlishchuk S.A.

doi:https://doi.org/

Petrik G.G.

Kafedra terapii #1 FPK i PPS Kubanskogo gosudarstvennogo meditsinskogo universiteta, Krasnodar

Pavlishchuk S.A.

Kafedra terapii #1 FPK i PPS Kubanskogo gosudarstvennogo meditsinskogo universiteta, Krasnodar

Metabolic and hemostatic characteristics of patients with type 2 diabetes mellitus differing in the severity of angiopathy

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Petrik G.G., Pavlishchuk S.A.

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Journal: Problems of Endocrinology. 2010;56(2): 15‑19

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Petrik GG, Pavlishchuk SA. Metabolic and hemostatic characteristics of patients with type 2 diabetes mellitus differing in the severity of angiopathy. Problems of Endocrinology. 2010;56(2):15‑19. (In Russ.)

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Abstract:

The objective of the present study was to identify risk factors of developing vascular disorders in patients at different stages of type 2 diabetes mellitus (DM2) by comprehensive analysis of metabolic parameters, hemograms, thrombocytic and plasma hemostasis. The study involved 75 patients (22 men and 53 women of mean age 57,3±9,7 years) having angiopathies of different severity. The data obtained confirmed the presence of risk factors of vascular pathology in different phases of DM2. All the examined patients including those without angiopathies in the early period of diabetes showed triglyceridemia, cholesterolemia, enhanced platelet aggregation activity, and shortened activated partial thromboplastin time. Patients with diabetic nephropathy at the stage of microalbuminuria and with non-proliferative retinopathy were distinct from the remaining ones in that they had significantly higher blood alpha-2 globulin and fibrinogen levels. Diabetic patients with micro- and macrovascular problems were characterized by marked dysproteinemia and abnormal platelet disaggregation.

Keywords:

angiopathies

parameters of metabolism

thrombocytic and plasma hemostasis

Authors:

Petrik G.G.

Kafedra terapii #1 FPK i PPS Kubanskogo gosudarstvennogo meditsinskogo universiteta, Krasnodar

Pavlishchuk S.A.

Kafedra terapii #1 FPK i PPS Kubanskogo gosudarstvennogo meditsinskogo universiteta, Krasnodar

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