Expression of somatostatin and dopamine receptors in ACTH-producing tumours

Dedov I.I.

Endocrinology Research Centre

Marova E.I.

Endocrinology Research Centrer

Abrosimov A.Iu.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Lapshina A.M.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Grigor'ev A.Iu.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Ablitsov Iu.A.

Natsional'nyĭ mediko-khirurgicheskiĭ tsentr im. N.I. Pirogova, Moskva

Kuznetsov N.S.

Endocrinology Research Centrer

Goncharov N.P.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Arapova S.D.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Rozhinskaia L.Ia.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Expression of somatostatin and dopamine receptors in ACTH-producing tumours

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Dedov I.I., Marova E.I., Abrosimov A.Iu., Lapshina A.M., Grigor'ev A.Iu., Ablitsov Iu.A., Kuznetsov N.S., Goncharov N.P., Arapova S.D., Rozhinskaia L.Ia.

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Journal: Problems of Endocrinology. 2010;56(1): 14‑18

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To cite this article:

Dedov II, Marova EI, Abrosimov AIu, et al. . Expression of somatostatin and dopamine receptors in ACTH-producing tumours. Problems of Endocrinology. 2010;56(1):14‑18. (In Russ.)

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This study was designed to compare immunoexpression of somatostatin receptors (SR)1-5 and dopamine receptors 2 (DR2) in pituitary and non-pituitary ectopic ACTH-producing tumours. A total of 35 patients were enrolled in the study including 21 with Cushing's disease (CD) and 14 with ACTH-ectopic syndrome (ACTH-ES) associated with carcinoid tumours of lungs (n=11), kidney (n=1), thymus (n=1) and with small-cell lung carcinoma (n=1). All patients with corticotropinomas exhibited expression of SR 1-5 dominated by SR-1 (57%). 81% of these tumours expressed two and more SR subtypes. DR2 expression was documented in 52% of the tumours and co-expression of DR2 with different SR subtypes in 29%. Neoplasms associated with ACTH-ES expressed SR with the predominance of SR-3 (72%). Half of these tumours co-expressed two and more SR subtypes. Expression of DR2 was demonstrated in 50% of the neoplasms associated with ACTH-ES; 38% of them co-expressed SR and DF2.

Keywords:

ACTH-producing tumours

immunoexpression of somatostatin and dopamine receptors

Authors:

Dedov I.I.

Endocrinology Research Centre

Marova E.I.

Endocrinology Research Centrer

Abrosimov A.Iu.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Lapshina A.M.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Grigor'ev A.Iu.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Ablitsov Iu.A.

Natsional'nyĭ mediko-khirurgicheskiĭ tsentr im. N.I. Pirogova, Moskva

Kuznetsov N.S.

Endocrinology Research Centrer

Goncharov N.P.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Arapova S.D.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Rozhinskaia L.Ia.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

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