Impact of reconstruction method on the quality of life in patients with BRCA1, BRCA2 gene mutations undergoing preventive mastectomy

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

SPIN RSCI: 5232-0412
Scopus AuthorID: 55461712100
ORCID: 0000-0003-4281-1947

Mistakopulo F.N.

Frau Clinic LLC

Zikiryakhodzhaev A.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Russia;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia;
Peoples’ Friendship University of Russia

SPIN RSCI: 8421-0364
Scopus AuthorID: 57220129122
ORCID: 0000-0001-7141-2502

Portnoy S.M.

Frau Clinic LLC

Sobolevskiy V.A.

Blokhin National Cancer Research Center

Krokhina O.V.

Blokhin National Cancer Research Center

Sukhotko A.S.

Moscow State University of Food Production

Impact of reconstruction method on the quality of life in patients with BRCA1, BRCA2 gene mutations undergoing preventive mastectomy

Authors:

Manturova N.E., Mistakopulo F.N., Zikiryakhodzhaev A.D., Portnoy S.M., Sobolevskiy V.A., Krokhina O.V., Sukhotko A.S.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2020;(4): 5‑10

DOI: 10.17116/plast.hirurgia20200415

Downloaded: 248

To cite this article:

Manturova NE, Mistakopulo FN, Zikiryakhodzhaev AD, Portnoy SM, Sobolevskiy VA, Krokhina OV, Sukhotko AS. Impact of reconstruction method on the quality of life in patients with BRCA1, BRCA2 gene mutations undergoing preventive mastectomy. Plastic Surgery and Aesthetic Medicine. 2020;(4):5‑10. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia20200415

Подписка 2025-2 (Plastic Surgery and Aesthetic Medicine)

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OBJECTIVE

To improve the quality of life in patients with BRCA1, BRCA2 gene mutations after simultaneous reconstructions during preventive mastectomy.

MATERIAL AND METHODS

The study included 78 patients with BRCA1, BRCA2 gene mutations. Breast cancer surgery and simultaneous preventive contralateral mastectomy were performed in 76 cases, bilateral preventive mastectomy — in 2 carriers of BRCA1 gene. Patients were divided into 2 groups depending on breast reconstruction method. In the 1^st group (n=36), radical subcutaneous/skin-sparing mastectomy was followed by simultaneous autologous flap reconstruction. In the 2^nd group (n=42), similar intervention was accompanied by simultaneous reconstruction with a silicone endoprosthesis (mesh implant/or acellular dermal matrix). All patients received combined/complex treatment depending on the stage of disease. Statistica v. 7 complex statistical package included multidimensional statistics and multivariate analysis. Quality of life was assessed using the BREAST-Q questionnaire.

RESULTS

We observed worse quality of life in the 1^st group compared to the 2^nd group according to all BREAST-Q items (p<0.05). Two patients who underwent bilateral preventive mastectomy were diagnosed with cr in situ in one of the mammary glands. None of the patients experienced progression of disease with local relapse and distant metastasis.

CONCLUSION

There was no cancer in the reconstructed breast, i.e. an efficacy of preventive surgery is 100%. Moreover, simultaneous reconstruction significantly improves the quality of life in these patients.

Keywords:

genetically associated breast cancer

BRCA1 and BRCA2 gene mutations

surgical prevention of breast cancer

Authors:

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

SPIN RSCI: 5232-0412
Scopus AuthorID: 55461712100
ORCID: 0000-0003-4281-1947

Mistakopulo F.N.

Frau Clinic LLC

Zikiryakhodzhaev A.D.

SPIN RSCI: 8421-0364
Scopus AuthorID: 57220129122
ORCID: 0000-0001-7141-2502

Portnoy S.M.

Frau Clinic LLC

Sobolevskiy V.A.

Blokhin National Cancer Research Center

Krokhina O.V.

Blokhin National Cancer Research Center

Sukhotko A.S.

Moscow State University of Food Production

Received:

05.06.2020

Accepted:

30.07.2020

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