In connection with the active development of science and technology in the past 10 years, new methods have been introduced into practical medicine to control a number of diseases and conditions. The use of new therapeutic techniques is of particular importance in oncology, which is associated with the severity of the course of tumor pathology in patients and with the particular difficulty in choosing treatments. Pancreatic cancer is today one of the most unfavorable tumors that are characterized by a high risk for tumor complications, a significant general health deterioration and a decrease in patient performance, and the high rate of untimely diagnosis and the low rates of survival in the patients. Due to the significant prevalence of the disease at the verification stage, a significant proportion of patients with this diagnosis cannot receive radical surgical treatment. Chemotherapy is the mainstay of specific treatment in these cases. High-intensity focused ultrasound therapy is one of the local therapy techniques used to enhance the efficiency of specific drug treatment in patients with locally advanced and generalized pancreatic cancer. The efficiency and safety of local treatment in combination with chemotherapy in this category of patients may suggest that it is advisable to perform this type of combined for the unoperated because of the existing somatic disorders in patients with localized pancreatic cancer. The described case suggests that high-intensity focused ultrasound therapy in combination with chemotherapy is justified in the unoperated patients with somatic disorders in the presence of pancreatic cancer.