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Stukan A.I.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Murashko R.A.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Bodnya V.N.

Department of Oncology with Course of Thoracic Surgery, Faculty for Postgraduate Training and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia

Makarova Yu.M.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Vasilenko I.N.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Topical issues of chemoradiotherapy for oropharyngeal squamous cell carcinoma: the efficiency and toxicity of chemotherapy regimens with the goal of radiomodification

Authors:

Stukan A.I., Murashko R.A., Bodnya V.N., Makarova Yu.M., Vasilenko I.N.

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Journal: P.A. Herzen Journal of Oncology. 2018;7(3): 61‑67

DOI: 10.17116/onkolog20187361

Views: 2284

Downloaded: 38

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To cite this article:

Stukan AI, Murashko RA, Bodnya VN, Makarova YuM, Vasilenko IN. Topical issues of chemoradiotherapy for oropharyngeal squamous cell carcinoma: the efficiency and toxicity of chemotherapy regimens with the goal of radiomodification. P.A. Herzen Journal of Oncology. 2018;7(3):61‑67. (In Russ.)
https://doi.org/10.17116/onkolog20187361

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The review discusses chemoradiotherapy, induction chemotherapy, and adjuvant chemotherapy for oropharyngeal squamous cell carcinoma. It considers the efficiency and toxicity of chemotherapy regimens with the goal of radiomodification. Concurrent high-dose cisplatin chemotherapy is indicated for patients with stage IV and T3N0—1 oropharyngeal squamous cell carcinoma who receive radical radiotherapy. Patients receiving adjuvant radiotherapy after surgical treatment in the presence of positive resection margins should undergo concurrent chemoradiotherapy using an intermittent high-dose cisplatin chemotherapy regimen. If there are contraindications to the use of high-dose cisplatin, routine adjuvant systemic chemotherapy is not recommended. Induction chemotherapy is not indicated for patients with oropharyngeal squamous cell carcinoma either. The data of multicenter randomized trials indicate that chemoradiotherapy improves locoregional control and overall survival rates in patients with oropharyngeal squamous cell carcinoma. To achieve regional control of the disease and overall survival benefits after concurrent chemoradiotherapy, it is necessary to administer cisplatin to a cumulative dose of 200—250 mg/m2. Concurrent weekly administration of cisplatin during chemoradiation therapy can be recommended to a patient only if there are contraindications to high-dose chemotherapy.

Keywords:

oropharyngeal carcinoma
high-dose cisplatin
cumulative dose
radiomodification
chemotherapy regimens

Authors:

Stukan A.I.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Murashko R.A.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Bodnya V.N.

Department of Oncology with Course of Thoracic Surgery, Faculty for Postgraduate Training and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia

Makarova Yu.M.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

Vasilenko I.N.

Clinical Oncology Dispensary One, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia

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