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Sidorov D.V.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Grishin N.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Lozhkin M.V.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Petrov L.O.

Herzen Moscow Oncology Research Institute of Healthcare Ministry of the Russian Federation — branch of National Medical Research Radiology Center

Troitskiĭ A.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Khoronenko V.E.

FGAOU VO «The First Moscow State Medical University named after I.M. Sechenov» Ministry of Health of Russia, Moscow, Russia

Filonenko E.V.

FGU Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Minzdravsotsrazvitiia Rossii, Moskva

Volchenko N.N.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena, Moskva

Kornietskaia A.L.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Sobolev D.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Cytoreductive surgery for mucinous adenocarcinoma of the appendix

Authors:

Sidorov D.V., Grishin N.A., Lozhkin M.V., Petrov L.O., Troitskiĭ A.A., Khoronenko V.E., Filonenko E.V., Volchenko N.N., Kornietskaia A.L., Sobolev D.D.

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Journal: P.A. Herzen Journal of Oncology. 2016;5(6): 21‑25

DOI: 10.17116/onkolog20165621-25

Views: 3320

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To cite this article:

Sidorov DV, Grishin NA, Lozhkin MV, et al. . Cytoreductive surgery for mucinous adenocarcinoma of the appendix. P.A. Herzen Journal of Oncology. 2016;5(6):21‑25. (In Russ.)
https://doi.org/10.17116/onkolog20165621-25

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Objective — to study the possibilities of cytoreductive interventions in combination with hyperthermic intraoperative intraperitoneal chemotherapy or intraoperative photodynamic therapy in patients with disseminated mucinous adenocarcinoma of the appendix. Subjects and methods. The investigation enrolled 38 patients aged 23 to 79 years with T3—4N0M1a mucinous adenocarcinoma of the appendix (pseudomyxoma peritonei), who had undergone cytoreductive surgery in combination with intraoperative methods of exposure of the tumor. Results. The paper presents an analysis by the peritoneal carcinomatosis index, the completeness of cytoreduction, the nature and severity of postoperative complications, and mortality rates. There were postoperative complications in 6 (15.7%) patients and a fatal outcome in one. Conclusion. Cytoreductive surgery for appendiceal pseudomyxoma is a highly effective and rather safe treatment.

Keywords:

mucinous adenocarcinoma of the appendix
pseudomyxoma
cytoreduction
carcinomatosis index
completeness of cytoreduction

Authors:

Sidorov D.V.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Grishin N.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Lozhkin M.V.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Petrov L.O.

Herzen Moscow Oncology Research Institute of Healthcare Ministry of the Russian Federation — branch of National Medical Research Radiology Center

Troitskiĭ A.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Khoronenko V.E.

FGAOU VO «The First Moscow State Medical University named after I.M. Sechenov» Ministry of Health of Russia, Moscow, Russia

Filonenko E.V.

FGU Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Minzdravsotsrazvitiia Rossii, Moskva

Volchenko N.N.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena, Moskva

Kornietskaia A.L.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Sobolev D.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

List of references:

  1. Amini A, Masoumi-Moghaddam S, Ehteda A, Morris DL. Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects. Orphanet J Rare Dis. 2014;9:71. doi:10.1186/1750-1172-9-71
  2. Moran B, Cecil T, Chandrakumaran K, Arnold S, Mohamed F, Venkatasubramaniam A. The results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in 1200 patients with peritoneal malignancy. Colorectal Dis. 2015;17(9):772-778. doi:10.1111/codi.12975
  3. Sugarbaker PH, Chang D, Stuart OA. Hyperthermic intraoperative toracoabdominal chemotherapy. Gastroenterol Res Pract. 2012;2012:623417. doi:10.1155/2012/623417
  4. Chua TC, Moran BJ, Sugarbaker PH, Levine EA, Glehen O, Gilly FN et al. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 2012;30:2449-2456. doi:10.1200/JCO.2011.39.7166
  5. Esquivel J, Averbach A. Laparoscopic cytoreductive surgery and HIPEC in patients with limited pseudomyxoma peritonei of appendiceal origin. Gastroenterol Res Pract. 2012;2012:981245. doi:10.1155/2012/981245
  6. Sparks DS, Morris B, Xu W, Fulton J, Atkinson V, Meade B, Lutton N. Cytoreductive surgery and heated intraperitoneal chemotherapy for peritoneal carcinomatosis secondary to mucinous adenocarcinoma of the appendix. Int Surg. 2015;100(1):21-28. doi:10.9738/INTSURG-D-14-00089.1
  7. Lord AC, Shihab O, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ. Recurrence and outcome after complete tumour removal and hyperthermic intraperitoneal chemotherapy in 512 patients with pseudomyxoma peritonei from perforated appendiceal mucinous tumours. Eur J Surg Oncol. 2015;41(3):396-399. doi:10.1016/j.ejso.2014.08.476
  8. Järvinen P, Ristimäki A, Kantonen J, Aronen M, Huuhtanen R, Järvinen H, Lepistö A. Comparison of serial debulking and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei of appendiceal origin. Int J Colorectal Dis. 2014;29(8):999-1007. doi:10.1007/s00384-014-1933-8
  9. Dubé P, Sideris L, Law C, Mack L, Haase E, Giacomantonio C et al. Guidelines on the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal surface malignancy arising from colorectal or appendiceal neoplasms. Curr Oncol. 2015;22(2):e100-e112. doi:10.3747/co.22.2058
  10. Singhi AD, Davison JM, Choudry HA, Pingpank JF, Ahrendt SA, Holtzman MP et al. GNAS is frequently mutated in both low-grade and high-grade disseminated appendiceal mucinous neoplasms but does not affect survival. Hum Pathol. 2014;45(8):1737-1743. doi:10.1016/j.humpath.2014.04.018

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