To further improve the quality of palliative care to cancer patients in the Samara Region, the authors created and introduced a system for the cure and organizational and methodical support of healthcare facilities in the management and follow-up of these patients with chronic pain syndrome. The main areas of cure were on-site audits of the quality of follow-up in Stage 4 cancer patients and a pain diagnosis and management educational program for cancer patients. Expert judgements of primary accounting records were made and the errors committed by therapists and practitioners in the management of cancer patients with chronic pain syndrome were recorded and analyzed during the audits. A classifier of errors and a model of their integral estimation were elaborated to analyze and summarize audit results. The analysis showed that the bulk in the pattern of registered defects was tactical errors (71.2%) associated with the wrong combinations and dosages of prescription narcotic drugs. The proportion of the clinical errors related to no use of third-degree analgesics and found in half of the patients to be checked was as high as 17.0%. The results of the given analysis formed the basis for the pain diagnosis and management education program annually implemented in the Samara Region. The developed forms and methods of the program for the cure and organizational and methodic support of an oncological component of the activities of the region’s healthcare facilities make it possible to identify institutions where the specialists commit the most serious errors in managing Stage 4 cancer patients and to promptly take optimal organizational decisions to eliminate the specific causes of this or that defect.