The paper gives a concise review of the world literature on and the first Russian clinical experience with an Evident microwave ablation system (Valleylab, USA) used for hepatectomy and percutaneous ablation of a liver metastatic focus. SII-SIII bisegmentectomy was performed using a microwave generator in a female patient with a solitary focus in the left hepatic lobe. Percutaneous mass ablation was carried out in another female patient with a small metastasis in the right hepatic lobe (SV). The application of a parenchymal dissection device during anatomic hepatectomy permitted this stage to be performed precisely, bloodlessly, and relatively rapidly. Percutaneous ablation using a cryogenic antenna could form an exposure area of sufficient volume, without giving rise to immediate complications. Our presented observations suggest that the Valleylab MV microwave ablator may be used for both anatomic and atypical hepatectomies and percutaneous ablation of liver metastatic foci. A 1.5-year follow-up of both female patients revealed no disease recurrence, including in the microwave ablation area, which may suggest the potential oncologic adequacy of this promising procedure.