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Voloznev L.V.

Kafedra radiobiologii i biofiziki FGBOU VPO "Moskovskaia gosudarstvennaia akademiia veterinarnoĭ meditsiny i biotekhnologii im. K.I. Skriabina"

The mechanisms for the development of metastatic skeletal lesion and the role of N-bisphosphonates in its therapy

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Voloznev L.V.

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Journal: P.A. Herzen Journal of Oncology. 2013;2(1): 73‑77

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Voloznev LV. The mechanisms for the development of metastatic skeletal lesion and the role of N-bisphosphonates in its therapy. P.A. Herzen Journal of Oncology. 2013;2(1):73‑77. (In Russ.)

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Metastatic bone lesions belong to secondary neoplasms, by ranking third in cancer incidence after lung and liver metastases. The mechanisms underlying a bone lesion are complex and result from the interaction between both the tumor and the bone system. The mechanism of action of bisphosphonates and the pathogenetic mechanisms of bone resorptive processes due to the influence of metastatic cells are shown. An understanding of a metastatic lesion process allows one to state the considerable role of using N-bisphosphonates and to introduce them into clinical practice to improve the results of treatment and quality of life in patients.

Keywords:

metastatic skeletal lesion
zoledronic acid
N-bisphosphonates

Authors:

Voloznev L.V.

Kafedra radiobiologii i biofiziki FGBOU VPO "Moskovskaia gosudarstvennaia akademiia veterinarnoĭ meditsiny i biotekhnologii im. K.I. Skriabina"

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