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Galstyan G.R.

Endocrinology Research Center

Shikh E.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

We’re Compensating!

Authors:

Galstyan G.R., Shikh E.V.

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Journal: Non Nocere. New Therapeutic Journal. 2025;(11): 90‑97

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To cite this article:

Galstyan GR, Shikh EV. We’re Compensating! Non Nocere. New Therapeutic Journal. 2025;(11):90‑97. (In Russ.)

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Использование инфографики авторами научных работ
Abstract:

An Interdisciplinary Approach to Vitamin B12 Deficiency: Endocrinology and Clinical Pharmacology.

Authors:

Galstyan G.R.

Endocrinology Research Center

Shikh E.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

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References:

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  2. Resolution of the V International Congress dedicated to World Obesity Day / Therapy school. [Electronic resource]. Accessed: September 2, 2025. https://obesity.therapy.school/upload/Rezolyucia%202023.pdf
  3. GBD2021 Nervous System Disorders Collaborators. Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024 Apr;23(4):344-381.  https://doi.org/10.1016/S1474-4422(24)00038-3
  4. Niafar M, Hai F, Porhomayon J, Nader ND. The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med. 2015 Feb;10(1):93-102.  https://doi.org/10.1007/s11739-014-1157-5
  5. Yang W, Cai X, Wu H, Ji L. Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta-analysis. J Diabetes. 2019 Sep;11(9):729-743.  https://doi.org/10.1111/1753-0407.12900
  6. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jan 27;13(2):395.  https://doi.org/10.3390/nu13020395
  7. Shivaprasad C, Gautham K, Ramdas B, Gopaldatta KS, Nishchitha K. Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus. Acta Diabetol. 2020 Sep;57(9):1073-1080. https://doi.org/10.1007/s00592-020-01526-4
  8. Pratama S, Lauren BC, Wisnu W. The efficacy of vitamin B12 supplementation for treating vitamin B12 deficiency and peripheral neuropathy in metformin-treated type 2 diabetes mellitus patients: A systematic review. Diabetes Metab Syndr. 2022 Oct;16(10):102634. https://doi.org/10.1016/j.dsx.2022.102634
  9. State Register of Medicines. Medicines. Glucophage®. Registration Certificate LP-No. (006054)-(RG-RU) dated June 28, 2024. Accessed: September 2, 2025. https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=5d72cf2e-3583-4cd2-8727-c54f27015a1e
  10. Hansen CS, Jensen JS, Ridderstråle M, Vistisen D, Jørgensen ME, Fleischer J. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. J Diabetes Complications. 2017 Jan;31(1):202-208.  https://doi.org/10.1016/j.jdiacomp.2016.08.025
  11. American Diabetes Association Professional Practice Committee. 1. Improving Care and Promoting Health in Populations: Standards of Care in Diabetes – 2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S14–S26.  https://doi.org/10.2337/dc25-S001
  12. Mokrysheva N.G., Shestakova M.V., Ametov A.S., et al. Insufficiency/deficiency of vitamin B12 in patients in the endocrinological practice. Diabetes mellitus. 2024;27(3):314-320. (In Russ.) https://doi.org/10.14341/DM13181
  13. Pop-Busui R, Ang L, Boulton AJM, Feldman EL, Marcus RL, Mizokami-Stout K, Singleton JR, Ziegler D. Diagnosis and treatment of painful diabetic peripheral neuropathy. – Arlington (VA): American Diabetes Association; February 2022.
  14. Vincenti A, Bertuzzo L, Limitone A, D’Antona G, Cena H. Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population. Nutrients. 2021 Jun 2;13(6):1913. https://doi.org/10.3390/nu13061913
  15. Andrès E, Dali-Youcef N, Vogel T, Serraj K, Zimmer J. Oral cobalamin (vitamin B(12)) treatment. An update. Int J Lab Hematol. 2009 Feb;31(1):1-8.  https://doi.org/10.1111/j.1751-553X.2008.01115.x
  16. Green R, Allen LH, Bjørke-Monsen AL, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017 Jun 29;3:17040. https://doi.org/10.1038/nrdp.2017.40
  17. Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014 Sep 4;349:g5226. https://doi.org/10.1136/bmj.g5226
  18. Kancherla V, Elliott JL Jr, Patel BB, et al. Long-term Metformin Therapy and Monitoring for Vitamin B12 Deficiency Among Older Veterans. J Am Geriatr Soc. 2017 May;65(5):1061-1066. https://doi.org/10.1111/jgs.14761
  19. Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care. 2000 Sep;23(9):1227-1231. https://doi.org/10.2337/diacare.23.9.1227
  20. Ekusheva EV, Shikh EV, Ametov AS, et al. The problem of vitamin B12 deficiency: relevance, diagnosis and targeted therapy (based on materials of an interdisciplinary expert council with international participation). S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11):17-25. (In Russ.) https://doi.org/10.17116/jnevro202112111117
  21. Elangovan R, Baruteau J. Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation? Front Pharmacol. 2022 Sep 29;13:972468. https://doi.org/10.3389/fphar.2022.972468
  22. Abdelwahab OA, Abdelaziz A, Diab S, et al. Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis. Ir J Med Sci. 2024 Jun;193(3): 1621-1639. https://doi.org/10.1007/s11845-023-03602-4
  23. Vidal-Alaball J, Butler CC, Cannings-John R, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004655. https://doi.org/10.1002/14651858.CD004655.pub2
  24. Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I, et al. Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomised, non-inferiority clinical trial (OB12). BMJ Open. 2020 Aug 20;10(8):e033687. https://doi.org/10.1136/bmjopen-2019-033687
  25. State Register of Medicines. Medicines. B12 Ankermann. Registration Certificate LP-No. (000075)-(RG-RU) dated July 21, 2025. Accessed: September 2, 2025. https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=ee904d62-8e5f-422c-b166-7bf6e0761876.pdf
  26. Koroleva IG, Shikh EV, Sizova ZhM, Zakharova VL. Possibilities of oral form of cyanocobalamin in pharmacological correction of vitamin B12 deficiency developed in patients with type 2 diabetes mellitus during treatment with metformin. Russian Journal of Preventive Medicine. 2025;28(9):64-69. (In Russ.) https://doi.org/10.17116/profmed20252809164
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