The role of chlamydial colonization of the gastrointestinal tract in the development and maintenance of chronic chlamydial infections

Bondareva N.E.; Koroleva E.A.; Zigangirova N.A.

doi:https://doi.org/10.17116/molgen201836041177

Bondareva N.E.

Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow, Russia

Koroleva E.A.

Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow, Russia

Zigangirova N.A.

Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow, Russia

The role of chlamydial colonization of the gastrointestinal tract in the development and maintenance of chronic chlamydial infections

Authors:

Bondareva N.E., Koroleva E.A., Zigangirova N.A.

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Journal: Molecular Genetics, Microbiology and Virology. 2018;36(4): 177‑181

DOI: 10.17116/molgen201836041177

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To cite this article:

Bondareva NE, Koroleva EA, Zigangirova NA. The role of chlamydial colonization of the gastrointestinal tract in the development and maintenance of chronic chlamydial infections. Molecular Genetics, Microbiology and Virology. 2018;36(4):177‑181. (In Russ.)
https://doi.org/10.17116/molgen201836041177

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)

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Abstract:

Diseases, caused by C. trachomatis, have an adverse impact on the health and reproductive function in women and men, leading the cause of infertility. Despite the fact that C. trachomatis is a sexually transmitted pathogen, adapted to the epithelial cells of the urogenital tract (UGT), it has a fairly wide tropism and can infect blood cells, epithelium of conjunctiva, synovial cells, hepatocytes, enteroendocrine cells and be detected in different gastrointestinal tract (GIT) in men and women. Data on infections in mice showed, that chlamydia can spread lympogenously/hematogenously in the body, colonize the intestine, persist in these organs for a long time without causing a significant pathology, but inducing chronic pathological inflammation in reproductive organs. In model C. muridarum shows the role of the conservative chlamydial protein Pgp3, encoded by the plasmid sequence, to establish colonization of the digestive tract. Accumulate experimental and clinical evidence, that intestine was favourable niche for persistence of chlamydia, where intracellular pathogen can avoid the competitive impact of the intestinal microflora, and due to immune homeostasis on the intestinal mucosa, the immune response is characterized by poor protection. It is likely, that the generalized urogenital chlamydial infection and colonization by chlamydia of digestive tract are the main causes for chronicity of infection and the development of pathology in the reproductive sphere, as well as in other organs. Proof of the role of this mechanism in formation of chronic infections will require new approaches to the diagnosis and treatment of chlamydiosis. These new data and is the subject of this review.

Keywords:

C trachomatis

chronic chlamydiosis

organs of the gastrointestinal tract (GIT)

generalization of infection

C trachomatis

chronic chlamydiosis

organs of the gastrointestinal tract (GIT)

generalization of infection

infectious process

pathology

generalization of infection

infectious process

pathology

review

infectious process

review

pathology

review

Authors:

Bondareva N.E.

Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow, Russia

Koroleva E.A.

Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow, Russia

Zigangirova N.A.

Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow, Russia

Close metadata

References:

Schachter J, Moncada J, Liska S, Shayevich C, Klausner JD. Nucleic acid amplification tests in the diagnosis of chlamydial and gonococcal infections of the oropharynx and rectum in men who have sex with men. Sex Transm Dis. 2008;35(7):637-642.
Peipert JF. Clinical practice. Genital chlamydial infections. N Engl J Med. 2003;349(25):2424-2430.
Haggerty CL, Gottlieb SL, Taylor BD, Low N, Xu F, Ness RB. Risk of sequelae after Chlamydia trachomatis genital infection in women. J Infect Dis. 2010;2012:134-155.
Zigangirova NA, Rumyantseva YP, Morgunova EY, Kapotina LN, Didenko LV, Kost EA, et al. Detection of C. trachomatis in the Serum of the Patients with Urogenital Chlamydiosis. Biomed Res Int. 2013;489.
Rank RG, Yeruva L. Hidden in plain sight: chlamydial gastrointestinal infection and its relevance to persistence in human genital infection. Infect Immun. 2014;82(4):1362-1371.
Meyer KF, Eddie B. Latent psittacosis infections in shell parakeets. Proc Soc Exp Biol Med. 1933;30:484-488.
York CJ, Baker JA. A new member of the psittacosislymphogranuloma group of viruses that causes infection in calves. J Exp Med. 1951;93:587-604.
Omori T, Morimoto T, Harada K, Inaba Y, Ishii S, Matumoto M. Miyagawanella: psittacosis-lymphogranuloma group of viruses. I. Excretion of goat pneumonia virus in feces. Jpn J Exp. 1957;27:131-143.
Kawakami Y, Kaji T, Sugimura K, Omori T, Matumoto M. Miyagawanella: psittacosis-lymphogranuloma group of viruses. V. Isolation of a virus from feces of naturally infected sheep. Jpn J Exp Med. 1958;28:51-58.
Dungworth DL, Cordy DR. The pathogenesis of ovine pneumonia. II. Isolation of virus from faeces; comparison of pneumonia caused by faecal, enzootic abortion and pneumonitis viruses. J Comp Pathol. 1962;72:71-79.
Kölbl O. Research on the incidence of Miyagawanella in pigs. Wien Tieraerztl Monat. 1969;56:332-335.
Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA. 2008;105(39):15064-15069.
Zhong G. Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract — A Two-Hit Hypothesis. Trends Microbiol. 2018;26(7):611-623.
Zhang Q, Huang Y, Gong S, Yang Z, Sun X, Schenken R, et al. In Vivo and Ex Vivo Imaging Reveals a Long-Lasting Chlamydial Infection in the Mouse Gastrointestinal Tract following Genital Tract Inoculation. Infect Immun. 2015;83(9):3568-3577.
Dai J, Zhang T, Wang L, Shao L, Zhu C, Zhang Y, et al. Intravenous Inoculation with Chlamydia muridarum Leads to a Long-Lasting Infection Restricted to the Gastrointestinal Tract. Infect Immun. 2016;84(8):2382-2388.
O’Connell CM, Ingalls RR, Andrews CWJr, Scurlock AM, Darville T. Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease. J Immunol. 2007;179(6):4027-4034.
Lei L, Chen J, Hou S, Ding Y, Yang Z, Zeng H. Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum. Infect Immun. 2014;82(3):983-992.
Shao L, Melero J, Zhang N, Arulanandam B, Baseman J, Liu Q, et al. The cryptic plasmid is more important for Chlamydia muridarum to colonize the mouse gastrointestinal tract than to infect the genital tract. PLoS One. 2017;12(5):e0177691.
Shao L, Zhang T, Melero J, Huang Y, Liu Y, Liu Q, et al. The Genital Tract Virulence Factor pGP3 Is Essential for Chlamydia muridarum Colonization in the Gastrointestinal Tract. Infect Immun. 2017;86(1). pii: e00429-17.
Li Z, Chen D, Zhong Y, Wang S, Zhong G. The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells. Infect Immun. 2008;76(8):3415-3428.
Hou S, Dong X, Yang Z, Li Z, Liu Q, Zhong G. Chlamydial Plasmid-Encoded Virulence Factor Pgp3 Neutralizes the Antichlamydial Activity of Human Cathelicidin LL-37. Infect Immun. 2015;83(12):4701-4709.
Galaleldeen A, Taylor AB, Chen D, Schuermann JP, Holloway SP, Hou S, et al. Structure of the Chlamydia trachomatis immunodominant antigen Pgp3. J Biol Chem. 2013;288(30):22068-22079.
Morrison RP, Caldwell HD. Immunity to murine chlamydial genital infection. Infect Immun. 2002;70(6):2741-2751.
Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, et al. Vaccines. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015;348(6241):aaa8205.
Vlcek KR, Li W, Manam S, Zanotti B, Nicholson BJ, Ramsey KH, et al. The contribution of Chlamydia-specific CD8+ T cells to upper genital tract pathology. Immunol Cell Biol. 2016;94(2):208-212.
Manam S, Nicholson BJ, Murthy AK. OT-1 mice display minimal upper genital tract pathology following primary intravaginal Chlamydia muridarum infection. Pathog Dis. 2013;67(3):221-224.
Johnson RM, Kerr MS, Slaven JE. An atypical CD8 T-cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin-13. Immunology. 2014;142(2):248-257.
Murthy AK, Li W, Chaganty BK, Kamalakaran S, Guentzel MN, Seshu J, et al. Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection. Infection and Immunity. 2011;79(7):2928-2935.
Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, et al. Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog. 2011;7(5):e1001339.
Manam S, Thomas JD, Li W, Maladore A, Schripsema JH, Ramsey KH, et al. Tumor necrosis factor (TNF) receptor superfamily member 1b on CD8+ T cells and TNF receptor superfamily member 1a on non-CD8+ T cells contribute significantly to upper genital tract pathology following chlamydial infection. J Infect Dis. 2015;211(12):2014-2022.
Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013;500(7461):232-236.
Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013;341(6145):569-573.
Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, et al. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39+ Foxp3+ T cells and Treg function. Gut Microbes. 2015;6(4):234-242.
Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016;351(6279):1329-1333.
Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest. 1999;104(6):777-785.
Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004;173(6):4020-4029.
Pashko YuP. Vyyavlenie S.trachomatis v syvorotke krovi i bioptatah zhelchnogo puzyrya i pecheni pri ostryh i hronicheskih holecistitah. Idei Pastera v bor’be s infekciyami. Materialy IV mezhdunarodnoj konferencii. SPb., 2—4 iyunya 2008;68. (In Russ.)
Dlugosz A, Muschiol S, Zakikhany K, Assadi G, D’Amato M, Lindberg G. Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study. Gut Pathog. 2014;6:24.
Yeruva L, Spencer N, Bowlin AK, Wang Y, Rank RG. Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection. Pathog Dis. 2013;68(3):88-95.
Benn PD, Rooney G, Carder C, Brown M, Stevenson SR, Copas A. Chlamydia trachomatis and Neisseria gonorrhoeae infection and the sexual behaviour of men who have sex with men. Sex Transm Infect. 2007;83(2):106-112.
Dunlop EMC, Hare MJ, Darougar S, Jones B. Chlamydial isolates from the rectum in association with chlamydial infection of the eye or genital tract. II. Clinical aspects. 1970;507-512.
Jones RB, Rabinovitch RA, Katz BP, Batteiger BE, Quinn TS, Terho P, et al. Chlamydia trachomatis in the pharynx and rectum of heterosexual patients at risk for genital infection. Ann Intern Med. 1985;102(6):757-762.
Schachter J, Grossman M, Sweet RL, Holt J, Jordan C, Bishop E. Prospective study of perinatal transmission of Chlamydia trachomatis. JAMA. 1986;255(24):3374-3377.