Polymorphism of two dopamine degradation enzyme genes (COMT and MAOA) in hadza and datoga populations

Fekhretdinova D.I.; Sukhodolskaya E.M.; Shibalev D.V.; Lazebnyy O.E.; Butovskaya M.L.; Ryskov A.P.; Vasil’yev V.A.

doi:https://doi.org/10.17116/molgen20183603138

Fekhretdinova D.I.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Sukhodolskaya E.M.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Shibalev D.V.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Lazebnyy O.E.

Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Butovskaya M.L.

Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia;
Russian State University for Humanities, Moscow, 125993, Russia

Ryskov A.P.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Vasil’yev V.A.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Polymorphism of two dopamine degradation enzyme genes (COMT and MAOA) in hadza and datoga populations

Authors:

Fekhretdinova D.I., Sukhodolskaya E.M., Shibalev D.V., Lazebnyy O.E., Butovskaya M.L., Ryskov A.P., Vasil’yev V.A.

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Journal: Molecular Genetics, Microbiology and Virology. 2018;36(3): 38‑42

DOI: 10.17116/molgen20183603138

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Fekhretdinova DI, Sukhodolskaya EM, Shibalev DV, Lazebnyy OE, Butovskaya ML, Ryskov AP, Vasil’yev VA. Polymorphism of two dopamine degradation enzyme genes (COMT and MAOA) in hadza and datoga populations. Molecular Genetics, Microbiology and Virology. 2018;36(3):38‑42. (In Russ.)
https://doi.org/10.17116/molgen20183603138

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)

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Abstract:

The molecular genetic analysis of the loci of two dopamine degradation enzyme genes (COMT rs4680 and MAOA-uVNTR) in African ethnic populations Hadza (n=353) and Datoga (n=465) was performed. Comparative analysis of allele and genotype frequencies of the COMT rs4680 locus showed significant differences between the Hadza and the Datoga males (p<0.001) and no significant differences between the females of the two tribes (p=0.064; p=0.076). As for the MAOA-uVNTR loci, no statistical differences were found between both males (p=0.993) and women (p=0.229; 0.057) of the two populations. Moreover, women did not differ from the men within each tribe on the allele and genotype frequencies of the MAOA-uVNTR. The obtained data can be used to determine the association between genetic variants and different forms of aggressive behavior.

Keywords:

catecholamine degradation genes

population genetic parameters

aggressive behavior

traditional societies

Hadza

Datoga

Authors:

Fekhretdinova D.I.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Sukhodolskaya E.M.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Shibalev D.V.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Lazebnyy O.E.

Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Butovskaya M.L.

Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia;
Russian State University for Humanities, Moscow, 125993, Russia

Ryskov A.P.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

Vasil’yev V.A.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

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References:

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