Introduction. Research into septic conditions has led to significant progress in determining the body’s response to infection. However, there is still a need for early indicators of the development of organ dysfunction or deterioration of the body’s response, which will allow to choose the most appropriate therapeutic intervention as early as possible. The aim of the work: was to evaluate the clearance of proadrenomedulline and procalcitonin as markers of prognosis of short-term mortality (28 days) in patients of the intensive care units with signs of sepsis or severe infections. Material and methods. A total of 119 patients were included in the study, which were divided into two groups depending on the outcome: non-survivors (55 people) and survivors (64 people). For biomarkers (procalcitonin, proadrenomedulline, lactate, creatinine, serum bilirubin, leukocyte, neutrophils and platelets count) and their clearance was calculated the median value, interqvartile ranges (25th and 75th), and, with Mann—Whitney test, determined the significance of differences of the measured indicators in groups at admission, at 1 and 5 days spent in intensive care. Results. Significant differences (p<0.05) in the groups were identified: on admission for proadrenomedulline, creatinine, lactate; after 1 day — only for clearance of procalcitonin and proadrenomedulline; on day 5 — for procalcitonin and proadrenomedulline and their clearance, for creatinine and C-reactive protein. The ROC-analysis method for these laboratory parameters was used to determine decision limits for predicting the outcome of the disease with maximum sensitivity and specificity. Conclusions. This study has shown the importance of simultaneous calculation of the clearance of procalcitonin and proadrenomedulline, which may to increase their diagnostic value and can be useful to determine the risk of adverse outcome of patients in intensive care units.