The aim of this research is to compare the accuracy of the results of lipidograms in self-collected and nurse-collected capillary blood samples using the Roche Cobas c 702 analyzer. Material and methods. The study was conducted on 49 male and female volunteers aged from 18 to 65 years. The biomaterial was taken sequentially: first it was self-collection then the capillary blood was taken by a nurse. The paired difference in the results obtained by different methods of taking biomaterial was calculated in absolute and relative units by the statistical bootstrap method. In addition, a regression analysis of the results was carried out and a comparison of the mean values for the pairs with the CVa data according to the RCV formula. Results. In case of self-collection capillary blood, minor deviations in the results of the biomarkers are observed in comparison with the nurse-collected samples: cholesterol (0.14%; R2 = 0.9739), HDL (–0.09%; R2 = 0.9895), LDL (0.22%; R2 = 0.9909), Tg (3.74%; R2 =0.9847), Apo A-1 (–0.06%; R2 = 0.9714) and Apo B (3.52%; R2 = 0.9447). All values of the difference in results taking into account their 95% confidence intervals fit into the CVa for the methods under consideration. When the centrifugation of capillary blood samples was delayed up to 24 hours, no statistically significant changes were observed relative to similar results of studies performed in accordance with preanalytical rules (centrifugation delay not more than 2 hours). Conclusions. The absence of a statistically significant difference in the results of an analysis of the lipid spectrum of blood in self-collection and nurse-collected capillary blood samples was demonstrated.