Background. Genetic abnormalities are associated with specific aberrant immunophenotype of the leukemia’s cells. In acute myeloid leukemia the most frequent of them are t(8;21); inv(16) or t(16;16); t(15;17). In adult patients with B lymphoblastic leukemia/lymphoma t(9;22)(q34;q11.2) is detect more often. Aim. The use of modern techniques of immunophenotyping to identify aberrant immunophenotype associated with the respective recurrent chromosomal aberrations. Results. For immunophenotyping of the leukemia’s cells are used flow cytometry. The cases of acute leukemia, which immunophenotypic profile assumes the presence of concrete recurrent genetic abnormalities, are presented. So, the detection in a patient’s bone marrow sample blast myeloid cells population with immunophenotype CD117+++, CD34+++, HLA-DR+++, CD38+++, суМРО+++, CD13dim, CD33dim, CD56+, CD19dim, CD7dim has allowed to propose availability translocation t(8;21). In the other patient two populations of leukemia blasts were found out: 1) mature сells with high expression of antigens CD34, CD117, with features of the granulocytic differentiation; 2) more mature cells, not expressing CD34, CD117, with differentiation signs in direction to monocytopoiesis and granulocytopoiesis with the coexpression CD2 antigen, that indicated the damages of 16 chromosome (inv(16) or t(16;16)). In the third case population of blasts with bright homogeneous expression of the pan-myeloid antigen CD33, weak expression of the pan-myeloid antigen CD13 and early myeloid marker CD117, positive expression of the antigens CD9, CD64, cyMPO and negative HLA-DR expression were found out. Such immunophenotypic profile can give the possibility to predict presence t(15;17). Conclusion. In all cases of the acute myeloid leukemia chromosome abnormalities were proved by the genetic analysis. In patient with B lymphoblastic leukemia the expression of the pan-B cell’s markers CD19. cyCD79a and specific for this type of leukemia antigens profile CD10+++, CD13dim+, CD33dim+, CD66c+++, CD38−, was established. Further, genetic analysis revealed the existence of t(9;22)(q34;q11.2).