First description of cases of dermatomycosis caused by Trichophyton indotineae in the Ural region

Gerasimova N.A.; Yevstigneyeva N.P.; Guschin A.Ye.; Farina Yu.A.; Rabtsevich V.V.; Rimar O.G.

doi:https://doi.org/10.17116/klinderma202625021197

Gerasimova N.A.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0000-0001-5370-5571

Yevstigneyeva N.P.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0000-0003-3497-0673

Guschin A.Ye.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia

ORCID: 0000-0002-0399-1167

Farina Yu.A.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0009-0003-8119-0845

Rabtsevich V.V.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0009-0007-7414-5586

Rimar O.G.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

SPIN RSCI: 4714-2685
ORCID: 0000-0001-8597-9630

First description of cases of dermatomycosis caused by Trichophyton indotineae in the Ural region

Authors:

Gerasimova N.A., Yevstigneyeva N.P., Guschin A.Ye., Farina Yu.A., Rabtsevich V.V., Rimar O.G.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2026;25(2): 197‑206

DOI: 10.17116/klinderma202625021197

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To cite this article:

Gerasimova NA, Yevstigneyeva NP, Guschin AYe, Farina YuA, Rabtsevich VV, Rimar OG. First description of cases of dermatomycosis caused by Trichophyton indotineae in the Ural region. Russian Journal of Clinical Dermatology and Venereology. 2026;25(2):197‑206. (In Russ.)
https://doi.org/10.17116/klinderma202625021197

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

Abstract:

BACKGROUND

The active global spread of Trichophyton indotineae is a current problem of clinical mycology. It is a new type of dermatophyte that is aggressive and resistant to antibiotics in the absence of diagnostic methods available for routine practice. Discovery of the first cases of dermatophytosis caused by T. indotineae in the Moscow region determines the need to study the spread of this pathogen in other regions of the country, including the Urals.

OBJECTIVE

To determine the incidence rate of T. indotineae in the Ural region among patients with mycosis of the skin and its appendages.

MATERIAL AND METHODS

Molecular and biological methods were used to detect dermatophytes, identify T. indotineae and mutations of resistance to terbinafine in squalene epoxidase (SQLE) gene.

RESULTS AND CONCLUSIONS

Samples with DNA of T. mentagrophytes complex (43/13.3%), among which DNA from T. indotineae was identified in 9 (2.74%), were selected among the samples containing DNA of causative agents of mycosis, namely Trichophyton, Microsporum, Epidermophyton (n=328). The key demographic and clinical characteristics of a group of patients with trichophytosis caused by T. indotineae and the effectiveness of their treatment are described. The first case of dermatophytosis caused by T. indotineae in a child in Russia is described.

Keywords:

trichophytosis

Trichophyton mentagrophytes complex

Trichophyton indotineae

resistance to terbinafine

resistance mutations

squalene epoxidase (SQLE)

itraconazole

Authors:

Gerasimova N.A.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0000-0001-5370-5571

Yevstigneyeva N.P.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0000-0003-3497-0673

Guschin A.Ye.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia

ORCID: 0000-0002-0399-1167

Farina Yu.A.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0009-0003-8119-0845

Rabtsevich V.V.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

ORCID: 0009-0007-7414-5586

Rimar O.G.

Ural Research Institute for Dermatology, Venereology and Immunopathology, Yekaterinburg, Russia

SPIN RSCI: 4714-2685
ORCID: 0000-0001-8597-9630

Received:

16.03.2026

Accepted:

24.03.2002

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References:

Gupta AK, Susmita, Nguyen HC, Liddy A, Economopoulos V, Wang T. Terbinafine Resistance in Trichophyton rubrum and Trichophyton indotineae: A Literature Review. Antibiotics (Basel). 2025;14(5):472. https://doi.org/10.3390/antibiotics14050472
Gupta AK, Susmita, Nguyen HC, Liddy A, Talukder M, Wang T, Magal L, Chowdhary A, Shemer A, Saunte DML, Hay R, Piguet V. Trichophyton indotineae: Epidemiology, antifungal resistance and antifungal stewardship strategies. J Eur Acad Dermatol Venereol. 2026;40(1):29-45. https://doi.org/10.1111/jdv.20810
Al-Janabi AAHS. Guidelines for diagnosing and differentiating infection with antifungal-resistant Trichophyton indotineae from other dermatophytoses. Crit Rev Clin Lab Sci. 2026;63(2):135-146. https://doi.org/10.1080/10408363.2025.2551649
Rhodes J, Hui ST, Dellière S, Summerbell RC, Scott JA, Kaur A, Barton RC, Leitao R, Hemmings S, Goiriz R, Lambourne J, Farrer RA, Schelenz S, Hay RJ, Borman AM, Chowdhary A, Abdolrasouli A, Fisher MC. Emerging terbinafine-resistant Trichophyton indotineae between 2018 and 2023: a multinational genomic epidemiology study. Lancet Microbe. 2026;7(2): 101273. https://doi.org/10.1016/j.lanmic.2025.101273
Dos Santos AR, Uhrlaß S, Nenoff P, Gold JAW, Bhuiyan MSI, Goturu S, Gade L, Bagal UR, Peterson JG, Wiederhold NP, Lockhart SR, Järv H, Hameed AF, Szepietowski J, Vasani R, Singal A, Parnell L, Schwem B, Chiller T, Litvintseva AP, Chow NA, Verma SB. Global Emergence of Antifungal-Resistant Dermatophytosis Caused by Trichophyton indotineae (Formerly T. mentagrophytes ITS Genotype VIII): A Genomic Investigation Involving 14 Countries. Mycoses. 2025;68(8):e70101. https://doi.org/10.1111/myc.70101
Guschin AE, Romanova IV, Ilyin LA, Potekaev NN. First description of cases of superficial mycoses caused by the resistant to allylamines (terbinafine) «Indian» species of dermatophytes — Trichophyton indotineae, in Russian dermatovenereological practice. Russian Journal of Clinical Dermatology and Venereology. 2024;23(5):581-590. (In Russ.). https://doi.org/10.17116/klinderma202423051581
Guschin AE, Nosyreva KK, Negasheva ES, Polevshchikova SA, Sapozhnikova NA, Potekaev NN. First experience of Real-Time PCR method application for dermatophytosis diagnosis and its comparison with KOH-microscopy and mycological culture. Russian Journal of Clinical Dermatology and Venereology. 2023;22(4):382-391. (In Russ., In Engl.). https://doi.org/10.17116/klinderma202322041382
Chua KYL, Halliday CL, Mason A, Vogrin S, Knox J, Chen SC. Optimising the detection of Trichophyton indotineae and its prevalence in a large Australian laboratory. Pathology. 2025;57(6):762-766. https://doi.org/10.1016/j.pathol.2025.03.008
Chowdhary A, Singh A, Kaur A, Khurana A. The emergence and worldwide spread of the species Trichophyton indotineae causing difficult-to-treat dermatophytosis: A new challenge in the management of dermatophytosis. PLoS Pathog. 2022;18(9):e1010795. https://doi.org/10.1371/journal.ppat.1010795
Palepu S, Treat JR. Presumed Trichophyton indotineae Infection in Children: A Call for Heightened Clinical Awareness. Pediatr Dermatol. 2025;42(5): 1097-1098. https://doi.org/10.1111/pde.15933
Karaa S, Gits-Muselli M, Braesch C, Seyler M, Bourrat E. Extensive cutaneous dermatophytosis caused by Trichophyton indotineae: also consider in children [Original title: Dermatophytose cutanée extensive à Trichophyton indotineae: y penser aussi chez l‘enfant]. Ann Dermatol Venereol FMC. 2022;2(8S1):A200-A201.
Pavlović MD, Marzouk S, Beciri L. Widespread dermatophytosis in a healthy adolescent: the first report of multidrug-resistant Trichophyton indotineae infection in the UAE. Acta Dermatovenerol Alp Pannonica Adriat. 2024;33(1): 53-55. PMID: 38347717.