Linear IgA bullous dermatosis belongs to the groups of subepithelial bullous dermatoses and is characterized by chronic course, subepidermal bullae formation and linear IgA autoantibodies deposition along the basal membrane. The disease occurs in two age groups: children under 5 and adults over 60 years. BP180/collagen XVII/BPAg2, that is structural component of dermoepidermal adhesion complex, is the most frequent target for autoantibodies in this dermatosis. We present our own clinical case of patient who developed the disease at the age of 19. She complained of rashes on the scalp skin, upper and lower extremities at the first dermatologist’s appointment. Intense itching bothered subjectively. Provisional diagnosis, namely «another refined dermatitis?», was made after examination. Applying antihistaminic and topical combined drugs, containing glucocorticoid and antibiotic, was ineffective. Skin biopsy, histological and immunofluorescent examinations, allowing to made a «linear IgA bullous dermatitis» diagnosis, were performed at subsequent admission. The patient was prescribed treatment with dapsone at a dose of 50 mg 2 times per day per os for a long time under the control of general clinical laboratory tests. In addition, standard hyposensitization therapy with 10 ml of 30% sodium thiosulphate and 250 ml of 0.9% sodium chloride 1 time per day intravenously (treatment course is 9 infusions) was carried out at the day hospital. The spray of hydrochloride hydrotetracycline in combination with hydrocortisone 2 times a day for 7 days was applied externally to the lesions; the solution including boric acid, resortin, phenol and fuxin was applied 2 times a day for 14 days. Itching decreased significantly, erosions regressed with the formation of serous hemorrhagic dry crusts on the background of the treatment. Patient has been discharged from the hospital with improvement.