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Vladimirova E.V.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA

Murakov S.V.

Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the FMBA of Russia

Markova Yu.A.

Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Matushevskaya E.V.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA

Vladimirov A.A.

I.M. Sechenov First Moscow State Medical University

Kapuler O.M.

Center of Cosmetology, Plastic and Reconstructive Surgery

Bezugly A.P.

Academy of Postgraduate Education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency of Russia

Sirmays N.S.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies of the Federal Medical Agency;
Centre of Modern paediatrics

Petinati Ya.A.

Academy of Postgraduate Education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency of Russia

Acute generalized pustular psoriasis (Zumbusch type): successful treatment without biologics

Authors:

Vladimirova E.V., Murakov S.V., Markova Yu.A., Matushevskaya E.V., Vladimirov A.A., Kapuler O.M., Bezugly A.P., Sirmays N.S., Petinati Ya.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2023;22(1): 26‑32

DOI: 10.17116/klinderma20232201126

Read: 17448 times

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Table of contents

ACUTE GENERALIZED PUSTULAR PSORIASIS (ZUMBUSCH TYPE): SUCCESSFUL TREATMENT WITHOUT BIOLOGICS
ACUTE GENERALIZED PUSTULAR PSORIASIS (ZUMBUSCH TYPE): SUCCESSFUL TREATMENT WITHOUT BIOLOGICS

To cite this article:

Vladimirova EV, Murakov SV, Markova YuA, et al. Acute generalized pustular psoriasis (Zumbusch type): successful treatment without biologics. Russian Journal of Clinical Dermatology and Venereology. 2023;22(1):26‑32. (In Russ., In Engl.)
https://doi.org/10.17116/klinderma20232201126

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Mechanism of action of various therapies for viti­ligo. Pharmacologist’s and dermatovenerologist’s perspective. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(6):734-741
Abstract:

BACKGROUND

Psoriasis is a chronic inflammatory disease predominantly affecting the skin. Acute generalized pustular psoriasis (GPP) is one of the rarest and most severe types of psoriasis. GPP manifests as spontaneously occurring specific skin lesions and is accompanied by a worsening of the general condition (fever, chills, malaise, nausea, severe pain, joint pain). Among the factors provoking pustular psoriasis are abrupt withdrawal of systemic steroid drugs, pregnancy, hypocalcemia, upper respiratory tract infections, and mental disorders. The main pathophysiological mechanism of the occurrence and progression of GPP is the migration of polymorphonuclear leukocytes from the vascular wall into the tissues and the activation of interleukins and nonspecific cytokines. Acitretin, cyclosporine, and methotrexate are used as first-line therapy. In addition, retinoids are also used in the basic therapy of various types of psoriasis. Second-line therapy includes adalimumab, etanercept, PUVA therapy, topical corticosteroids, and topical calcipotriol. The UK National Institute for Health and Clinical Excellence (NICE) has issued guidelines on non-biological therapies.

OBJECTIVE

A clinical case of Zumbusch-type GPP in a 25-year-old patient with a history of the disease since 3 years old is described.

MATERIAL AND METHODS

Treatment included cyclosporine A in the first phase and the combination of retinoids with total PUVA therapy in the second phase.

RESULTS

This treatment method made it possible to achieve 100% regression of the rash and ensure the absence of relapses without expensive biologicals.

CONCLUSION

The results suggest that effective treatment of acute GPP (Zumbusch type) is possible without biological therapy.

Keywords:

pustular psoriasis
Zumbusch psoriasis
cyclosporine A
acitretin
PUVA therapy

Authors:

Vladimirova E.V.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA

Murakov S.V.

Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the FMBA of Russia

Markova Yu.A.

Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Matushevskaya E.V.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA

Vladimirov A.A.

I.M. Sechenov First Moscow State Medical University

Kapuler O.M.

Center of Cosmetology, Plastic and Reconstructive Surgery

Bezugly A.P.

Academy of Postgraduate Education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency of Russia

Sirmays N.S.

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies of the Federal Medical Agency;
Centre of Modern paediatrics

Petinati Ya.A.

Academy of Postgraduate Education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency of Russia

Received:

03.08.2022

Accepted:

14.11.2022

Close metadata

References:

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