Dyshidrotic eczema is one of the common chronic skin diseases that are prone to a long course, the development of complications and resistance to therapy. The influence of exogenous factors (bacteria, fungi, endo- and exotoxins) with damage to the skin and the attachment of a secondary infection, as well as changes in immunological and biochemical processes accompanied by the activation of the inflammatory reaction, have a significant impact on the development of the disease. Patients are usually worried about severe itching, less often — pain in the affected area, physical, cosmetic and emotional discomfort. For external treatment of dyshidrotic eczema, it is especially advisable to use combined medications that have antibacterial, antifungal and anti-inflammatory effects. Studies have been conducted to evaluate the effectiveness of treatment of 18 patients with dyshidrotic eczema (the majority of patients with bacterial infection, about 20% with mixed bacterial candidiasis infection), a complicated secondary infection, cream for external use, which included components such as mometasone, gentamicin, econazole and dexpanthenol. The use of the cream 2 times a day for 14 days significantly reduced the severity of the clinical manifestations of the disease and improved the quality of life of patients. The combined composition of the cream provided relief of the main symptoms of the disease (itching, weeping, inflammatory manifestations, dryness, peeling and cracks) due to the antibacterial, antifungal and anti-inflammatory effects. As a result of exposure to the etiopathogenetic links of dyshidrotic eczema, the clinical effect manifested itself already 7 days after the start of treatment with the cream.