Comprehensive therapy for atopic dermatitis in children: focus on probiotics and external therapy

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Silina L.V.

Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

Chaplygin A.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Ustinov M.V.

IPK FMBA Rossii;
KVD #30 Moskvy

Laseev D.I.

Mordovia Republican Clinic of Skin and Venereal Diseases, Saransk, Russia, 430032

Ilyukhina E.V.

Starooskolsky Dermatovenerologic Clinic, Stary Oskol, Russia

Comprehensive therapy for atopic dermatitis in children: focus on probiotics and external therapy

Authors:

Silina L.V., Chaplygin A.V., Ustinov M.V., Laseev D.I., Ilyukhina E.V.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2019;18(6): 776‑783

DOI: 10.17116/klinderma201918061776

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To cite this article:

Silina LV, Chaplygin AV, Ustinov MV, Laseev DI, Ilyukhina EV. Comprehensive therapy for atopic dermatitis in children: focus on probiotics and external therapy. Russian Journal of Clinical Dermatology and Venereology. 2019;18(6):776‑783. (In Russ.)
https://doi.org/10.17116/klinderma201918061776

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

Atopic dermatitis (AD) is an important medical and social problem due to the steady increase in morbidity, chronic recurrence and the difficulty of choosing a treatment method. Currently, an increasing role in the pathogenesis of AD is given to the features of human intestinal microbiotics. The correction of intestinal microbiocenosis is important in the treatment of AD in children. One of the most studied and tested probiotic strains is Lactobacillus rhamnosus ATCC 53103 (Lactobacillus rhamnosus GG or LGG); the article discusses the mechanisms of LGG action in AD and allergy (suppression of expression of the genes encoding subunits of the allergy mediating high affinity receptor IgE — FCER1, and H4-receptor histamine on human peripheral blood fat cells). Based on the data of the presented literature review, the authors substantiate indications for the use of LGG in children to prevent early allergy manifestations and in the complex therapy of AD. Outdoor therapy is an obligatory part of the complex treatment of LGG. It should be differentiated to account for pathological changes in the skin. The aim of AD external therapy is not only to treat inflammation and itching, but also to restore the water-lipid layer and barrier function of the skin, as well as to ensure daily care. Local glucocorticosteroids are recommended as first-line drugs for the treatment of exacerbations of AD, as well as drugs for starting therapy; the search for new drugs in this group for complex therapy of AD in children remains relevant.

Keywords:

complex therapy of atopic dermatitis

methylprednisolone aceponate

Lactobacillus rhamnosus GG

Authors:

Silina L.V.

Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

Chaplygin A.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Ustinov M.V.

IPK FMBA Rossii;
KVD #30 Moskvy

Laseev D.I.

Mordovia Republican Clinic of Skin and Venereal Diseases, Saransk, Russia, 430032

Ilyukhina E.V.

Starooskolsky Dermatovenerologic Clinic, Stary Oskol, Russia

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References:

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