Comprehensive therapy for atopic dermatitis in children: focus on probiotics and external therapy

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Silina L.V.

Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

Chaplygin A.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Ustinov M.V.

IPK FMBA Rossii;
KVD #30 Moskvy

Laseev D.I.

Mordovia Republican Clinic of Skin and Venereal Diseases, Saransk, Russia, 430032

Ilyukhina E.V.

Starooskolsky Dermatovenerologic Clinic, Stary Oskol, Russia

Comprehensive therapy for atopic dermatitis in children: focus on probiotics and external therapy

Authors:

Silina L.V., Chaplygin A.V., Ustinov M.V., Laseev D.I., Ilyukhina E.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2019;18(6): 776‑783

DOI: 10.17116/klinderma201918061776

Views: 2151

Downloaded: 79

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Silina LV, Chaplygin AV, Ustinov MV, Laseev DI, Ilyukhina EV. Comprehensive therapy for atopic dermatitis in children: focus on probiotics and external therapy. Russian Journal of Clinical Dermatology and Venereology. 2019;18(6):776‑783. (In Russ.)
https://doi.org/10.17116/klinderma201918061776

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)

Close metadata

Atopic dermatitis (AD) is an important medical and social problem due to the steady increase in morbidity, chronic recurrence and the difficulty of choosing a treatment method. Currently, an increasing role in the pathogenesis of AD is given to the features of human intestinal microbiotics. The correction of intestinal microbiocenosis is important in the treatment of AD in children. One of the most studied and tested probiotic strains is Lactobacillus rhamnosus ATCC 53103 (Lactobacillus rhamnosus GG or LGG); the article discusses the mechanisms of LGG action in AD and allergy (suppression of expression of the genes encoding subunits of the allergy mediating high affinity receptor IgE — FCER1, and H4-receptor histamine on human peripheral blood fat cells). Based on the data of the presented literature review, the authors substantiate indications for the use of LGG in children to prevent early allergy manifestations and in the complex therapy of AD. Outdoor therapy is an obligatory part of the complex treatment of LGG. It should be differentiated to account for pathological changes in the skin. The aim of AD external therapy is not only to treat inflammation and itching, but also to restore the water-lipid layer and barrier function of the skin, as well as to ensure daily care. Local glucocorticosteroids are recommended as first-line drugs for the treatment of exacerbations of AD, as well as drugs for starting therapy; the search for new drugs in this group for complex therapy of AD in children remains relevant.

Keywords:

complex therapy of atopic dermatitis

methylprednisolone aceponate

Lactobacillus rhamnosus GG

Authors:

Silina L.V.

Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

Chaplygin A.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Ustinov M.V.

IPK FMBA Rossii;
KVD #30 Moskvy

Laseev D.I.

Mordovia Republican Clinic of Skin and Venereal Diseases, Saransk, Russia, 430032

Ilyukhina E.V.

Starooskolsky Dermatovenerologic Clinic, Stary Oskol, Russia

List of references:

Clinical recommendations. Atopic dermatitis in children. Union of Pediatricians of Russia, Ministry of Health of the Russian Federation, 2016. (In Russ.)
Tochilina AG, Belova IV, Solovyeva IV, et al. Formation of microflora of the intestines of a child in ontogenesis and prevention development of dysbiosis with the help of the author’s probiotics of the LB-complex group. Modern problems of science and education. 2016;5:337. (In Russ.)
Zakharova IN, Dmitrieva YuA. Intestinal microbiota and the use of probiotics from the perspective of evidence-based medicine. Con Med. Pediatrics (App.). 2016;4:24-28 (In Russ.)
Kummeling I, Thijs C, Penders J, at al. Etiology of atopy in infancy: the KOALA Birth Cohort Study. Pediatr Allergy Immunol. 2005;16:679-684.
Legatzki A, Rosler B, von Mutius E. Microbiome diversity and asthma and allergy risk. Curr. Allergy Asthma Rep. 2014;14(10):466.
Surzhik AV. Influence of probiotic culture Lactobacillus rhamnosus GG (LGG) on immune response of organism. Vopr sovr pediatr. 2009;2(8):54-58. (In Russ.)
Yan F, Polk DB. Lactobacillus rhamnosus GG: An Updated Strategy to Use Microbial Products to Promote Health. Functional food reviews (Print). 2012;4(2):77-84.
Belkaid Y, Harrison OJ. Homeostatic immunity and the microbiota. Immunity. 2017;46(4):562–576. https://doi.org/10.1016/j.immuni.2017.04.008
Hepworth MR, Fung TC, Masur SH, et al. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells. Science (New York, NY). 2015;348(6238):1031-1035. https://doi.org/10.1126/science.aaa4812
Hepworth MR, Monticelli LA, Fung TC, et al. Innate lymphoid cells regulate CD4+ T cell responses to intestinal commensal bacteria. Nature. 2013;498(7452):113-117. https://doi.org/10.1038/nature12240
Gury-BenAri M, Thaiss CF, Serafini N. The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome. Cell. 2016;166(5):1231-1246. https://doi.org/10.1016/j.cell.2016.07.043 Epub 2016 Aug 18
Segers ME, Lebeer S. Towards a better understanding of Lactobacillus rhamnosus GG — host interactions. Microbial Cell Factories. 2014;13(Suppl 1):S7. https://doi.org/10.1186/1475-2859-13-S1-S7
Kalliomaki M, Salminen S, Pousssa T, et al. Probiotic and prevention of atopic disease: 4-years follow-up of randomized placebo-controlled trial. Lancet. 2003;361:1869-1871.
Gonsorunova DS, Ogorodova LM, Fyodorova OS, et al. The participation of T-regulatory cells in the immune response in atopic dermatitis. Bulletin of Siberian medicine. 2011;4:82-88. (In Russ.)
Kerimova MK. Microbial landscape of the contents of the intestines and sputum of frequently ill children. Kazan Medical Journal. 2016;6:850-853. (In Russ.)
Kalliomaki M, Isolauri E. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol. 2003 Feb;3(1):15-20.
Andreeva IV. Modern evidence of the effectiveness of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb-12 in pediatric practice. Questions of modern pediatrics. 2011;1:50-57. (In Russ.)
Khavkin AI. Intestinal microecology and allergies. The attending physician. 2003;2:14-16. (In Russ.)
Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997;99:179-185.
Johnson-Henry KC, Donato KA, Shen-Tu G, et al. Lactobacillus rhamnosus strein GG prevents enterohemorrhagic Esherichia coli O157:H7-induced chages in epithelial barrier function. Infect Immune. 2008;76:1340-1348.
Rakoff-Nahoum S, Paglino J, Eslami-Yarzaneh F, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118:229-241.
Oksaharji A, Kankainen M, Kekkonen RA et al. Probiotic Lactobacillus rhamnosus downregulatess FCER1 and HRH4 expression in human mast cell. World J Gastroenterol. 2011;17:750-759.
Pessi T, Sutas Y, Hurme M, Isolauri E.Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin Exp Allergy. 2000;30:1804-1808.
Nermes M, Kantele JM, Atosuo TJ, et al. Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis. Clin Exp Allergy. 2011 Mar;41(3): 370-377. https://doi.org/10.1111/j.1365-2222.2010.03657.x Epub 2010 Dec 1
Volkova EN, et al. Methylprednisolone aceponate in the treatment of chronic dermatoses: an analysis of tactical application errors. Russian Journal of Clinical Dermatology and Venereology = Klinicheskaya dermatologiya i venerologiya. 2010;5:84-88. (In Russ.)
Zaumseil RP, Fuhrman H, et al. Methylprednisolone aceponate (Advantan) — an effective topical corticoid therapy with few side effects. Jahrbuch der Dermatol. 1992;3:247-263.
Meffert H, Schuppler J. Methylprednisolone aceponate lotion for treatment of acute eczema. Z Hautkr. 1999;74:88-94.
Ruzicka T. Methylprednisolone aceponate in eczema and other inflammatory skin disorders — a clinical update. Int J Clin Pract. 2006;60(1):85-92.
Mensing H, Lorenz B. Experience with methylprednisolone aceponate in patients suffering from acute and chronic eczema. Results of a large observational study. Z Hautkr. 1998;73:281-285.
Blume-Peytavi U, Wahn U. Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011 May;25(5):508-515. https://doi.org/10.1111/j.1468-3083.2010.03942.x
Luger TA. Balancing efficacy and safety in the management of atopic dermatitis: the role of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011 Mar;25(3):251-258.
Ernandez E. New cosmetology. 2012:75-77. (In Russ.)
Chamlin SL, Kao J, Frieden IJ, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol. 2002 Aug; 47(2):198-208.
Khlebnikov AN, Petrunin DD, Molochkov AV. Lipids of the human epidermis (fundamental information and clinical implementation). Study Guide; editor LYu Zarankina; 2015:26-28. (In Russ.)
Leung D, Nicklas R, Li J, et al. Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters. Ann. Allergy Asthma Immunol. 2004;9(Suppl 2):1-21.
Ishikawa J, Abe A, Jin K, et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol. 1991;96(4):523-526.
Janssens M, van Smeden J, Gooris GS, et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res. 2012;53(12):2755-2766.
Man MQ, Feingold KR, Thornfeldt CR, Elias PM. Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol. 1996;106(5):1096-1101.
Svirshchevskaya EV, Matushevskaya EV. Topical corticosteroids and blockers calcineurin in dermatology. Modern probl dermatovenerol immunol med cosmetol. 2012;1:57-62. (In Russ.)

Close metadata

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.