Objective: to study the species composition of the skin microflora in case of microbial eczema in adults. Material and Methods. The patients with microbial eczema aged 18 to 90 years were examined in the Regional Dermatovenerologic Clinics of Kursk and Belgorod. The main group of the examined patients consisted of 228 patients, of whom 132 were men (57.9%) and 96 were women (42.1%); control group included 95 healthy adults. Differences in sex and age between the study groups are not statistically significant. Results. In 118 (51.8%) patients, the pathological process on the skin was widespread, in 110 (48.2%), it was limited. The initial values of the EASI index ranged from 4.5 to 26.7 for all patients and averaged at 18.6. A positive correlation was found between the age and course of eczema (r = 0.3) in patients over the age of 50 years. Studies of skin microflora revealed a disruption of the microbiocenosis of the skin in patients both in quantitative terms and in terms of species composition. Of the 228 patients examined, a total 226 (99.1%) has staphylococcus isolated from infected foci: 145 (63,5%) — Staphylococcus aureus, 100 (43,9%) — St.epidermidis, 9 (3,9%) — St.saprofytis. In 32 (14%) out of 228 patients the cultures contained Streptococcus pyogenes, in 10 (4,4%) Propionibacterium, in 11 (4,8%) Corinebacterium, in 15 (6,5%) E.coli, in 4 (1,8%) Proteus, in 5 (2,2%) Klebsiella. During mycological examination, yeast fungi (38.2%), dermatophytes (31.5%), mold fungi (20.4%) and associations of several fungi (16%) were cultured in 29.0 ± 4.1% of patients with microbial eczema and fungal colonization. Patients with skin colonization by non-staphylococcus microflora of bacterial etiology and their association with fungi were present in a negligible proportion. The data obtained indicate significant dysbiotic changes in the skin microflora in case of microbial eczema.