Involutive changes of the skin are inevitably accompanied by reduction in the synthesis of collagen and in the rate of its metabolism. To restore and reinforce the dermal skeleton, various injection techniques are widely used in cosmetology, including the use of collagen preparations. Material and methods. The study included 60 patients (mean age, 48±7.6 years) with involutive changes in the facial skin. All patients underwent a course of biorevitalizer injections into the facial skin. The patients were allocated into two groups of 30 subjects each, depending on the used agent. Participants in the 1st group were injected with collagen biomaterial, and patients in the 2nd group received a biorevitalizer containing unstabilized high molecular weight hyaluronic acid. The study design and results are published in the international Clinical Trials database [1]. Results. According to the data of physical examination, 3D photography, clinical scales, global aesthetic improvement scale (GAIS), and instrumental diagnostics, a pronounced improvement in correction of involutive changes in the facial skin occurred in patients of both groups after completion of the course. This indicates a high efficiency of both therapies. According to the skin elasticity indicator, application of collagen biomaterial provided a significantly more pronounced effect.