Kaposi’s Sarcoma (CS) is a malignant vascular neoplasm characterized by viral etiology and multifactorial genesis. It is believed that type 8 human herpesvirus (HHV-8) plays a major role in development of this disease, but an additional condition is required (immune dysregulation, HIV infection, local chronic inflammation, etc.) to form CS. The disease can be both indolent and aggressive; involving either only the skin or additionally involving lymph nodes, the gastrointestinal tract, and other organs. Most patients are males; in the case of the conventional type, middle-aged and elderly. There are four types of CS depending on the main etiological factor. Histological and immunohistochemical presentation of the disease is in general the same for all clinical types. According to the literature, the overall therapy response rate is 35—50%. Topical therapy is used in the case of the conventional type of CS; surgical resection is used in the case of solitary neoplasms. The authors report the case of the development of the conventional type of CS in a 50-years-old female. Combination topical therapy (surgical resection and postoperative wound treatment with low-temperature plasma) provided complete remission of the disease that persists for 3 years.