The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Molochkova Iu.V.

MONIKI im. M.F. Vladimirskogo

Molochkov A.V.

FGBU "Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo" RAMN, Moskva

Amkhadova M.A.

Moscow Regional Research and Clinical Institute, Moscow, Russia, 129110

A novel approach to the treatment of vulvovaginal gingival syndrome

Authors:

Molochkova Iu.V., Molochkov A.V., Amkhadova M.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2018;17(2): 77‑80

DOI: 10.17116/klinderma201817277-80

Views: 4226

Downloaded: 38

Download PDF (RU)
Contact the author
Table of contents

A NOVEL APPROACH TO THE TREATMENT OF VULVOVAGINAL GINGIVAL SYNDROME
A NOVEL APPROACH TO THE TREATMENT OF VULVOVAGINAL GINGIVAL SYNDROME

To cite this article:

Molochkova IuV, Molochkov AV, Amkhadova MA. A novel approach to the treatment of vulvovaginal gingival syndrome. Russian Journal of Clinical Dermatology and Venereology. 2018;17(2):77‑80. (In Russ.)
https://doi.org/10.17116/klinderma201817277-80

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Close metadata

Lichen planus (LP) is an inflammatory disease that affects the skin, mucous membranes and skin appendages. About 25% of females suffering from the LP have vulvovaginal lesions. In 1982, M. Pelisse described one of the types of the erosive LP, which is characterized by a triad of symptoms, including vulvar, vaginal, and gingival lesions with pronounced tendency to scarring, adhesions, and stenosis. The diagnosis is established based on clinical examination and confirmed by histological examination of lesions. Vulvovaginal Gingival Syndrome (VGS) is characterized by chronic course, often relapses, and sometimes non-synchronous manifestation of certain symptoms. In the case of resistance to treatment and extensive process, systemic therapy with prednisolone, azathioprine, cyclosporine, griseofulvin, acitretin, synthetic antimalarials, metronidazole, and biological agents is carried out, which is not always effective and is often accompanied by adverse effects and complications. We have successfully applied the method of adaptive immunotherapy in patients with VGS, including photopheresis based on leukapheresis, UV-A irradiation of peripheral blood mononuclear cells isolated after administration of oral 8-methoxypsoralen followed by their subsequent reinfusion to the patient. We report a case demonstrating high efficacy of photopheresis in a VGS patient with the relapse-free period of more than 4 years.

Keywords:

erosive lichen planus
vulvovaginal gingival syndrome
photopheresis

Authors:

Molochkova Iu.V.

MONIKI im. M.F. Vladimirskogo

Molochkov A.V.

FGBU "Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo" RAMN, Moskva

Amkhadova M.A.

Moscow Regional Research and Clinical Institute, Moscow, Russia, 129110

List of references:

  1. Molochkova YuV, Khlebnikova AN. Clinical and pathological associations of lichen planus. Rus j skin veneral dis. 2016;5:286-295. (In Russ.) https://doi.org/10.18821/1560-9588-2016-19-5-286-290
  2. Scully C, Hegarty A. The oral cavity and lips. In: Burns T, Breathnach SM, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology. 8-th ed. Singapore: Wiley Blackwell; 2010;69.1-69.129.
  3. Goldstein AT, Metz A. Vulvar lichen planus. Clin Obstet Gynecol. 2005 Dec;48(4):818-823.
  4. Sharma N, Malhotra SK, Kuthial M, Chahal KS. Vulvo-vaginal ano-gingival syndrome: Another variant of mucosal lichen planus. Indian J Sex Transm Dis. 2017 Jan-Jun;38(1):86-88. https://doi.org/10.4103/0253-7184.203432
  5. Pelisse M, Leibowitch M, Sedel D, Hewitt J. Un nouveau syndrome vulvo‐vagino‐gingival. Lichen plan erosive plurimuqueux. Ann Dermatol Vénéréol. 1982;109:797-798.
  6. McPherson T, Cooper S. Vulval lichen sclerosus and lichen planus. Dermatol Ther. 2010 Sep-Oct;23(5):523-532. https://doi.org/10.1111/j.1529-8019.2010.01355.x
  7. Bunker CB., Neill SM. The genital, perianal and umbilical regions. In: Rook`s Textbook of Dermatology. 7-th ed./eds. Burns DA, Breathnach SM, Cox N, Griffiths C. Oxford: Blackwell Scientific Publications Ltd. 2004;68.1-68.104.
  8. Vasudevan B, Neema S, Verma R, Deb P, Kharayat V, Sethumadhavan T. Vulvovaginal-gingival syndrome and esophageal involvement in lichen planus. Indian J Dermatol Venereol Leprol. 2016 Mar-Apr;82(2):209-211. https://doi.org/10.4103/0378-6323.168939
  9. Wojnarowska F, Cooper SM. In: Dermatology. Eds. Bolognia JL, Jorizzo JL, Schaffer JV. Edinburg Mosby. 2003;1099-1113.
  10. Setterfield JF, Neill S, Shirlaw PJ, Theron J, Vaughan R, Escudier M, Challacombe SJ, Black MM. The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele. J Am Acad Dermatol. 2006 Jul;55(1):98-113.
  11. Kulthanan K, Jiamton S, Varothai S, Pinkaew S, Sutthipinittharm P. Direct immunofluorescence study in patients with lichen planus. Int J Dermatol. 2007 Dec;46(12):1237-1241. https://doi.org/10.1111/j.1365-4632.2007.03396.x
  12. McPherson T, Cooper S. Vulval lichen sclerosus and lichen planus. Dermatol Ther. 2010 Sep-Oct;23(5):523-532. https://doi.org/10.1111/j.1529-8019.2010.01355.x
  13. Dermatology by T. Fitzpatrick. Atlas - guide. A second Russian ed. Eds. Wolf K, Johnson R, Surmond D. Tr. from English. M.: Praktika, 2007;1248. (In Russ.)
  14. Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Int J Dermatol. 2009 Jul;48(7):682-694. https://doi.org/10.1111/j.1365-4632.2009.04062.x
  15. Büyük AY, Kavala M. Oral metronidazole treatment of lichen planus. J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):260-262.
  16. Ho JK, Hantash BM. Treatment of recalcitrant vulvovaginal gingival syndrome with adalimumab. J Am Acad Dermatol. 2011 Aug;65(2):e55-e57. https://doi.org/10.1016/j.jaad.2010.10.034
  17. Gerber M, Gmeinhart B, Volc-Platzer B, Kalhs P, Greinix H, Knobler R. Complete remission of lichen-planus-like graft-versus-host disease (GVHD) with extracorporeal photochemotherapy (ECP). Bone Marrow Transplant. 1997 Mar;19(5):517-519.
  18. Schwartz J, Gonzalez J, Palangio M, Klainer AS, Bisaccia E. Extracorporeal photochemotherapy in progressive systemic sclerosis: a follow-up study. Int J Dermatol. 1997 May;36(5):380-385.
  19. Molochkov VA, Kildushevsky AV, Karzanov OV. First Russian experience in the treatment of pemphigus with the use of extracorporeal photopheresis. Russian journal of skin and venereal diseases. 2002;6:24-28 (In Russ.)
  20. Zouboulis CC, Schmuth M, Doepfmer S, Dippel E, Orfanos CE. Extracorporeal photopheresis of cutaneous T-cell lymphoma is associated with reduction of peripheral CD4+ T lymphocytes. Dermatology. 1998;196(3):305-308.
  21. Fimiani M, Di Renzo M, Rubegni P. Mechanism of action of extracorporeal photochemotherapy in chronic graft-versus-host disease. Br J Dermatol. 2004 Jun;150(6):1055-1060.
  22. Andreu G, Leon A, Heshmati F, Tod M, Menkes CJ, Baudelot J, Laroche L. Extracorporeal photochemotherapy: evaluation of two techniques and use in connective tissue disorders. Transfus Sci. 1994 Dec;15(4):443-454.
  23. Rook AH, Suchin KR, Kao DM, Yoo EK, Macey WH, DeNardo BJ, Bromely PG, Geng Y, Junkins-Hopkins JM, Lessin SR. Photopheresis: clinical applications and mechanism of action. J Investig Dermatol Symp Proc. 1999 Sep;4(1):85-90.
  24. Bécherel PA, Bussel A, Chosidow O, Rabian C, Piette JC, Francès C. Extracorporeal photochemotherapy for chronic erosive lichen planus. Lancet. 1998 Mar, 14;351(9105):805.
  25. Guyot AD, Farhi D, Ingen-Housz-Oro S, Bussel A, Parquet N, Rabian C, Bachelez H, Francès C. Treatment of refractory erosive oral lichen planus with extracorporeal photochemotherapy: 12 cases. Br J Dermatol. 2007 Mar;156(3):553-556.
  26. Elewa R, Altenburg A, Zouboulis CC. Recalcitrant severe erosive cutaneous lichen planus treated with extracorporeal photopheresis monotherapy. Br J Dermatol. 2011 Aug;165(2):441-443. https://doi.org/10.1111/j.1365-2133.2011.10378.x
  27. Madnani N. Vulvar lichen planus. In: Lichen Planus. 1st ed. eds. U Khopker, A Valia. New Delhi: Jaypee Brothers; 2013;116-122.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.