In most cases of dermatitis and dermatosis, the symptoms of sensitive or intolerant skin are observed along with disease-specific basic rash elements, including irritation, subjective sense of discomfort, tightness, and burning, which often tend to increase when using standard topical treatment. For this reason, administration of adjuvant agents is required, which result in alleviation of these additional clinical symptoms and, at the same time, have certain therapeutic potential. In addition, patients with sensitive skin, in particular those who underwent cosmetic procedures, quite often seek advice from dermatologist, which necessitates administration of topical agents to relieve irritation and restore the skin barrier function. Objective — the study is aimed at assessing the efficacy of Aven thermal water in patients with sensitive skin, including those who underwent cosmetic procedures, as well as in treatment of patients with acute or chronic diseases with pathological process localized on the face. Material and methods. A total of 794 patients were observed. All patients used Aven thermal water TID for 7 days as a part of combination therapy or monotherapy. Results. Administration of Aven thermal water as monotherapy or in combination with medicinal treatment in 794 patients with sensitive skin, allergic or inflammatory skin diseases, or after cosmetic treatment demonstrated significant improvement of all dermatologic status indexes, which is indicative of the advisability of its administration in this category of patients. According to patients, the use of Aven thermal water results in strong effect, contributing to relief of inflammation, reduces the subjective symptoms associated with increased sensitivity of the skin, which, along with the ease of use and lack of side effects, leads to high patient compliance to this method of therapy.