Herpetic infection: mechanisms of latency and reactivation. Potential to control the infection

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The potential mechanisms that regulate the latency and limit reactivation of herpesviruses are analyzed. The relations between the herpes virus and the host immune system are described. Factors contributing to maintaining the latent infection and reactivation of viral replication are discussed. The use of acyclic nucleosides, including valacyclovir, is one of the strategies to control viral replication. The study involved 10 women with recurrent genital herpes accompanied by symptoms of persistent genital itching. The clinical effect (elimination of itching) was achieved in 8 patients by applying the complex antiviral therapy with drugs Virdel (valacyclovir) and Lavomax (tilorone hydrochloride) for 12 weeks.

Keywords:

herpes infection

latency

reactivation

valacyclovir (Virdel)

Tilorone (Lavomax)

Authors:

Kasikhina E.I.

State Educational Institution of additional professional education "Russian Academy of Continuous Medical Education"

Glazko I.I.

State Educational Institution of Additional Professional Education «Russian Medical Academy of Postgraduate Education»

Chekmarev A.S.

FGBU "Uchebno-nauchnyĭ meditsinskiĭ tsentr Upravleniia delami Prezidenta RF"

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