A prospective, randomized study comparing 150 patients undergoing laparoscopic operations (110 patients undergoing laparoscopic cholesystectomy and 40 patients laparoscopic fundoplication) with standard CO2 insufflation vs those receiving warmed, humidified CO2 was performed. All patients were randomized into 2 groups - 84 receiving standard CO2 insufflation (control group) and 66 receiving warmed, humidified CO2 (main group). Main variables included patient core temperature, postoperative pain, analgesic requirements and other postoperative dates. We revaeled that warmed, humidified CO2 has advantages that were statistically significant. Patients undergoing warmed, humidified carbon dioxide (CO2) insufflation for maintain a warmer intraoperative core temperature, and have less postoperative pain and need less analgesic requirements than patients with standard CO2 insufflation.