The efficacy of the percutaneous transluminal balloon angioplasty in patients with critical ischemia of the lower limbs and diabetes mellitus was analyzed. The study included 102 patients with septic complications of the diabetic foot syndrome. The main group consisted of 37 patients, who received both the traditional conservative therapy and the endovascular angioplasty. The study proves that the endovascular interventions by diabetic foot syndrome are effective and justified. Revascularisation permits the minimal resectional interventions on the foot, stop the ischemia and minimize the number of repeated necrectomies and high amputations. The diabetic foot syndrome is represented as a multidisciplinary problem.