The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection

Larichev A.B.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Shishlo V.K.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Lisovskiĭ A.V.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Chistiakov A.L.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection

Authors:

Larichev A.B., Shishlo V.K., Lisovskiĭ A.V., Chistiakov A.L.

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Journal: Pirogov Russian Journal of Surgery. 2011;(7): 31‑35

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To cite this article:

Larichev AB, Shishlo VK, Lisovskiĭ AV, Chistiakov AL. The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection. Pirogov Russian Journal of Surgery. 2011;(7):31‑35. (In Russ.)

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The study covers treatment results of 220 patients operated on ventral hernia and in vivo experimental treatment of 36 rats proved the nitrogen monoxide (NO) to be the effective means of wound infection prophylaxis. NO potentiates antiseptic effects, minimizing intraoperative wound contamination. It, besides, stimulates endothelial and basal cells of epidermis proliferation. Wound infection was observed only in 9,8% of patients, treated with NO intraoperatively. All cases of infective complications were serous and infiltrative, but not purulent.

Keywords:

operative wound

wound infection

nitrogen monoxide

treatment results

Authors:

Larichev A.B.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Shishlo V.K.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Lisovskiĭ A.V.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Chistiakov A.L.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

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