The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection

Larichev A.B.; Shishlo V.K.; Lisovskiĭ A.V.; Chistiakov A.L.

doi:https://doi.org/

Larichev A.B.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Shishlo V.K.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Lisovskiĭ A.V.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Chistiakov A.L.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection

Authors:

Larichev A.B., Shishlo V.K., Lisovskiĭ A.V., Chistiakov A.L.

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Journal: Pirogov Russian Journal of Surgery. 2011;(7): 31‑35

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To cite this article:

Larichev AB, Shishlo VK, Lisovskiĭ AV, Chistiakov AL. The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection. Pirogov Russian Journal of Surgery. 2011;(7):31‑35. (In Russ.)

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

The study covers treatment results of 220 patients operated on ventral hernia and in vivo experimental treatment of 36 rats proved the nitrogen monoxide (NO) to be the effective means of wound infection prophylaxis. NO potentiates antiseptic effects, minimizing intraoperative wound contamination. It, besides, stimulates endothelial and basal cells of epidermis proliferation. Wound infection was observed only in 9,8% of patients, treated with NO intraoperatively. All cases of infective complications were serous and infiltrative, but not purulent.

Keywords:

operative wound

wound infection

nitrogen monoxide

treatment results

Authors:

Larichev A.B.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Shishlo V.K.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Lisovskiĭ A.V.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

Chistiakov A.L.

Iaroslavskaia gosudarstvennaia meditsinskaia akademiia

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References:

Abushkin I.A., Abushkina V.G., Privalov V.A. Napryazhenie kisloroda v tkanyakh rany v protsesse ee zazhivleniya. Vestn khir 2002; 161: 1: 51-54.
Borodin I.F., Skobei E.V., Akulik V.P. Khirurgiya posleoperatsionnykh gryzh zhivota. Minsk: Belarus' 1986; 159.
Vyrenkov Yu.E., Moskalenko V.I., Shishlo V.K. Eksperimental'noe obosnovanie vozmozhnosti primeneniya kompleksnogo lecheniya ognestrel'nykh ran s ispol'zovaniem monooksida azota i limfogennoi terapii. Khirurg 2009; 9: 5-12.
Gostishchev V.K., Lipatov K.V., Emel'yanov A.Yu. i dr. Novye tekhnologii na osnove ispol'zovaniya oksida azota v lechenii gnoinykh ran. Infektsiya v khirurgii - problema sovremennoi meditsiny. M 2002; 13-15.
Grachev S.V. NO-terapiya - novoe napravlenie v meditsine. Vzglyad v budushchee. NO-terapiya: teoreticheskie aspekty, klinicheskii opyt i problemy primeneniya ekzogennogo oksida azota v meditsine. M 2001; 1-10: 19-22.
Grushko V.I. Primenenie plazmennogo potoka v kompleksnom lechenii gnoinykh ran: Avtoref. dis. … kand. med. nauk. M 2008; 22.
Darvin V.V., Zemlyanoi V.P., Mal'tsev P.A. Lechenie gnoinykh ran chelyustno-litsevoi oblasti s ispol'zovaniem monooksida azota. Rany i ranevaya infektsiya. Yaroslavl' 2007; 102-105.
Efimenko N.A., Khrupkin V.I., Marakhonich L.A. i dr. Vozdushno-plazmennye potoki i NO-terapiya - novaya tekhnologiya v klinicheskoi praktike voennykh vrachebno-profilakticheskikh uchrezhdenii. Voen-med zhurn 2005; 5: 51-54.
Kabisov R.K., Shekhter A.B., Pekshev A.V. i dr. Rol' ekzogennoi NO-terapii v sisteme kompleksnogo lecheniya ran i ranevoi patologii u onkologicheskikh bol'nykh. Ros onkol zhurn 2000; 4: 16-22.
Lipatov K.V., Sopromadze M.A., Shekhter A.B. i dr. Ispol'zovanie gazovogo potoka, soderzhashchego oksid natriya (NO-terapiya), v kompleksnom lechenii gnoinykh ran. Khirurgiya 2002; 2: 41-43.
Lourens D.R., Benitt P.N. Klinicheskaya farmakologiya. M: Meditsina 1993; 1: 639.
Lutsevich O.E., Shirinskii V.G., Shekhter A.B. i dr. Stimulyatsiya reparativnykh protsessov pri zazhivlenii ran. Khirurgiya 2008; 6: 6-10.
Marakhonich L.A. Primenenie plazmennykh potokov v lechenii ognestrel'nykh ran i ikh oslozhnenii: Avtoref. dis. … d-ra med. nauk. M 1997; 266.
Moskalenko V.I. Kompleksnoe lechenie ognestrel'nykh ranenii s ispol'zovaniem oksida azota i limfogennykh metodov: Avtoref. dis. … d-ra med. nauk. M 2006; 32.
Navashin S.M., Fomina I.P. Ratsional'naya antibiotikoterapiya. M: Meditsina 1982; 495.
Pekshev A.V. Pervyi opyt primeneniya ekzogennoi NO-terapii dlya lecheniya posleoperatsionnykh ran i luchevykh reaktsii u onkologicheskikh bol'nykh. Ros onkol zhurn 1992; 1: 24-29.
Rany i ranevaya infektsiya. Pod red. M.I. Kuzina i B.M. Kostyuchenka. M: Meditsina 1990; 592.
Reshetov I.V., Kabisov R.K., Shekhter A.B. i dr. Primenenie vozdushno-plazmennogo apparata Plazon v rezhime koagulyatsii i NO-terapii pri rekonstruktivno-plasticheskikh operatsiyakh u onkologicheskikh bol'nykh. Annaly plasticheskoi, rekonstruktivnoi i esteticheskoi khirurgii 2000; 4: 24-39.
Chumasov E.I., Ryazhkin G.A., Kashkov G.A. Elektronno-mikroskopicheskoe izuchenie ranevogo protsessa ognestrel'noi rany v eksperimente. Ognestrel'naya rana cheloveka. Tez. dokl. Leningrad 1981; 48-49.
Shekhter A.B., Grachev S.V. Primenenie ekzogennogo oksida azota v meditsine: mediko-biologicheskie osnovy, kliniko-morfologicheskie aspekty, mekhanizmy, problemy i perspektivy. NO-terapiya: teoreticheskie aspekty, klinicheskii opyt i problemy primeneniya ekzogennogo oksida azota v meditsine. M 2001; 27-35.