Use of the prokinetic domperidine in patients in the early postoperative period

Alekseeva E.V.; Fominykh V.P.; Tropskaia N.S.; Popova T.S.

doi:https://doi.org/

Alekseeva E.V.

Tsentral'naia klinicheskaia bol'nitsa s poliklinikoĭ UD Prezidenta RF, Moskva

Fominykh V.P.

Tsentral'naia klinicheskaia bol'nitsa s poliklinikoĭ UD Prezidenta RF, Moskva

Tropskaia N.S.

NII skoroĭ pomoshchi im. N.V. Sklifosovskogo, Moskva

Popova T.S.

NII skoroĭ pomoshchi im. N.V. Sklifosovskogo, Moskva

Use of the prokinetic domperidine in patients in the early postoperative period

Authors:

Alekseeva E.V., Fominykh V.P., Tropskaia N.S., Popova T.S.

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Journal: Pirogov Russian Journal of Surgery. 2010;(3): 62‑69

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Alekseeva EV, Fominykh VP, Tropskaia NS, Popova TS. Use of the prokinetic domperidine in patients in the early postoperative period. Pirogov Russian Journal of Surgery. 2010;(3):62‑69. (In Russ.)

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

The work focuses on the comparison of influence of domperidone and metoclopramide on rehabilitation of motor-evacuation function of stomach and small intestine in 82 patients with post-surgical flatulent distention. For group 1 (n=50) - metoclopramide was administered intravenously from the 1st postoperative day, 10 mg 3 times a day. For group 2 (n=32) - domperidone was used from the 1st postoperative day (motilium suspension), 20 ml 4 times a day. The results of gastrointestinal tract capacity rehabilitation were evaluated using the data of peripheral electrogastroenterography, enteral balance, a complex of radial diagnostics methods. Application of domperidone in patients with post-surgical flatulent distention resulted in quicker gastrointestinal tract motor resolution.

Keywords:

domperidone

metoclopramide

flatulent distention

intensive care unit patients

peripheral electrogastroenterography

Authors:

Alekseeva E.V.

Tsentral'naia klinicheskaia bol'nitsa s poliklinikoĭ UD Prezidenta RF, Moskva

Fominykh V.P.

Tsentral'naia klinicheskaia bol'nitsa s poliklinikoĭ UD Prezidenta RF, Moskva

Tropskaia N.S.

NII skoroĭ pomoshchi im. N.V. Sklifosovskogo, Moskva

Popova T.S.

NII skoroĭ pomoshchi im. N.V. Sklifosovskogo, Moskva

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References:

Gel'fand B.R., Martynov A.N., Gur'yanov V.A. i dr. Profilaktika stress-povrezhdenii verkhnego otdela zheludochno-kishechnogo trakta u bol'nykh v kriticheskikh sostoyaniyakh. Metod. rekomendatsii. M 2004; 18.
Ermolov A.S., Popova T.S., Pakhomova G.V., Uteshev N.S. Sindrom kishechnoi nedostatochnosti v neotlozhnoi abdominal'noi khirurgii (ot teorii k praktike). M: MedEkspert-Press 2005; 460.
Karimov Sh.I., Babadzhanov B.D. Diagnostika i lechenie ostrogo peritonita. Nal'chik 2006; 400.
Koryachkin A.A., Strashnov V.A., Chufarov V.N. Klinicheskie funktsional'nye i laboratornye testy v anesteziologii i intensivnoi terapii. St-Peterburg 2004; 304.
Martinchik A.N., Maev I.V., Yanushevich O.O. Obshchaya nutritsiologiya. M: MEDpress-inform 2005; 392.
Peritonit: Prakticheskoe rukovodstvo. Pod red. V.S. Savel'eva, B.R. Gel'fanda, M.I. Filimonova. M: Litterra 2006; 208.
Rebrov V.G., Loginov A.F., Kalinin A.V. Izmenenie elektricheskoi aktivnosti zheludka i kishechnika pri vozdeistvii motiliuma. Ros zhurn gastroenterol gepatol koloproktol 1997;4:42-45.
Rebrova O.Yu. Statisticheskii analiz meditsinskikh dannykh. Primenenie paketa prikladnykh programm STATISTICA. M: Media Sfera 2006; 312.
Tropskaya N.S. Mekhanizmy posleoperatsionnykh narushenii motorno-evakuatornoi funktsii zheludka i tonkoi kishki i ikh farmakologicheskaya korrektsiya: Avtoref. dis. … d-ra biol. nauk. M 2009; 42.
Khanevich M.D., Selivanov E.A., Starokon' P.M. Peritonit - infuzionno-transfuzionnaya i detoksikatsionnaya terapiya. M: MedEkspertPress 2004; 205.
Berger M.M., Mechanick J.I. Optimizing nutrition therapy in the ICU. Cur Opin Clin Nutr Metabol Care 2009;12:159-160.
Bouman G., van Achterberg T., Wanten G. A critical appraisal of indications for endoscopic placement of nasojejunal feeding tubes. Neth J Med 2008;66:2:67-70.
Chapman M., Fraser R., Vozzo R. et al. Antro-pyloro-duodenal motor responses to gastric and duodenal nutrient in critically ill patients. Gut 2005;54:10:1384-1390.
Deane A., Chapman M.J., Fraser R.J. et al. Wrld J Gastroenterol 2007;29:3909-3917.
Franzese A., Borrelli O., Corrado G. et al. Domperidone is more effective than cisapride in children with diabetic gastroparesis. Aliment Pharmacol Ther 2002;16:5:951-957.
Hegar B., Alatas S., Advani N. et al. Domperidone versus cisapride in the treatment of infant regurgitation and increased acid gastro-oesophageal reflux: a pilot study. Acta Paediat 2009;98:4:750-755.
Kreymann K.G., Berger M.M., Deutz N.E.P. et al. ESPEN Guidelines on Enteral Nutritional Intensive care. Clin Nutr 2006;25:210-223.
Landzinski J., Kiser T.H., Fish D.N. et al. Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. J Parenter Enteral Nutr 2008;32:1:45-50.
Nguyen N.Q., Chapman M., Fraser R.J. et al. Crit Care Med 2007;35:11:2561-2567.
Quigley E.M. Critical care dysmotility: abnormal foregut motor function in the ICU/ITU patient. Gut 2005;54:10:1351-1352.
Reddymasu S.C., Soykan I., McCallum R.W. Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology. Am J Gastroenterol 2007;102:2036-2045.
Reintam A., Parm P., Kitus R. et al. Gastrointestinal symptoms in intensive care patients. Acta Anaesthesiol Scand 2009;53:318-324.
Stephen A. McClave, Robert G. Martindale, Vincent W. Vanek et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically IllPatient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). J Parenter Enteral Nutr 2009;33:277-316.
Stroud M., Duncan H., Nightingale J. Guidelines for enteral feeding in adult hospital patients. Gut 2003;52(Suppl VII):v1-v12.
Waseem S., Moshiree B., Draganov P.V. Gastroparesis: Current diagnostic challenges and management considerations. Wrld J Gastroenterol 2009;15:25-37.