Objective — to summarize the results of replacement of affected supra-aortic arteries in patients with nonspecific aortoarteritis (NAA). Material and methods. A retro- and prospective analysis included 33 patients (3 (9.1%) men and 30 (90.9%) women aged 24.2±4.7 years) with NAA followed by lesion of supra-aortic arteries. Isolated lesion of carotid (n=13), subclavian (n=4) and vertebral arteries (n=1) were observed in 18 (54.5%) cases, combined lesion was observed in 15 (45.5%) patients (carotid and subclavian arteries in 11 patients, carotid, subclavian and vertebral arteries in 3 patients, subclavian and vertebral arteries in 1 patient). Involvement of abdominal aorta and its visceral branches were diagnosed in 15 (45.5%) patients. Chronic cerebrovascular insufficiency grade II was noted in 20 (60.6%) patients, grade III — in 7 (21.2%), grade IV — in 1 (3%) patients. Steal-syndrome occurred in 2 patients. Combination of cerebrovascular insufficiency with upper limb ischemia was observed in 13 (39.4%) patients. Results. Local extrathoracic carotid artery replacement was performed in 9 cases, total replacement — in 4 cases. Bilateral aorto-carotid bypass surgery and aorto-carotid-brachial bypass surgery through transpleural approach were made in 6 and 5 patients, respectively. Carotid-brachial (n=2) and carotid-subclavian (n=2) bypass grafting was performed in 4 patients with subclavian artery lesion. Patients with vertebral artery lesion (n=5) underwent carotid-vertebral bypass surgery (n=2) and aorto-carotid replacement with inclusion of vertebral artery (n=3). Synthetic vascular prostheses were used in 22 (66.7%) cases, autovenous grafts — in 11 (33.3%) cases. Synthetic graft thrombosis, brachioplexitis and Horner’s syndrome were diagnosed in early postoperative period in 3 patients, respectively. Lymphorrhea from a postoperative wound was noted in 2 cases. In long-term follow-up, intimal hyperplasia within proximal and distal anastomoses followed by recurrent occlusion of carotid artery occurred in 3 (9.1%) cases. Redo surgery was applied in only one case. Medication was preferred in other patients due to inoperability of the vessels. One patient died from progressive heart failure associated with vasorenal hypertension. Conclusion. Replacement and bypass procedures are preferred for patients with nonspecific aortoarteritis followed by diffuse lesion of supra-aortic vessels.