Objective — to study psychosomatic syndromes in patients with chronic coronary artery disease and their impact on its course in order to create clinical guides for cardiologists and physicians. Material and methods. The study enrolled 106 patients (38 females and 68 males, aged 66.8±9.4 years). All patients had myocardial infarction and/or myocardial revascularization at least 3 years prior to inclusion into study. Standard cardiac and psychopathological examinations were performed. Psychological tests included Short Health Anxiety Inventory (SHAI), assessment of quality of life (SF-36), NEO Five Factor Inventory, State-Trait Anxiety Inventory (STAI). Statistical analysis was performed using SPSS.19 software package. Fisher’s exact test with Bonferroni correction, Kruskal—Wallis and Mann—Whitney tests were calculated. Results. There were 3 types of psychosomatic syndromes associated with different types of illness behavior. Type I — chronic CAD with favorable course congruent to personality disorder (somatotonic/neuropathic accentuation), associated with adaptive behavior; type II — unfavorable course provoked by personality disorder (segmental depersonalization), associated with non-adaptive «health-ignoring» behavior; type III — unfavorable course comorbid to personality disorder (neuropathic accentuation), associated with non-adaptive «health-seeking» behavior. Psychometric examination revealed significant between-group differences for SHAI scale. Conclusion. Patients with chronic CAD should undergo SHAI examination to assess risk of non-adaptive illness behavior. Special monitoring program should be developed for early diagnosis of progressive cardiac disease in patients with «health-ignoring» behavior. Patients with «health-seeking» behavior need for psychiatric consultation for its correction and help of psychotherapist during cardiac rehabilitation.