Objective — to evaluate in-hospital neurological outcomes after simultaneous coronary artery bypass grafting (CABG) and carotid endarterectomy (CEE) depending on symptoms of cerebral atherosclerosis. Material and methods. Neurological outcomes were evaluated in 42 patients with multifocal atherosclerosis (MFA). Inclusion criterion: patients scheduled for simultaneous surgery (unilateral CEE and on-pump CABG). Exclusion criteria: combination of coronary artery disease with valvular heart disease, left ventricular aneurysm, chronic somatic diseases, aggravating neurological status and worsening prognosis. Survey methods: demographic, clinical, instrumental. Neuropsychological study included Mini-mental state examination (MMSE), Montreal cognitive assessment (MOCA) and frontal assessment batter (FAB). Memory, attention and neurodynamics were assessed using the hardware-software complex Status-PF 2—3 days prior to surgery and in 7—10 days after operation. Statistical analysis was carried out using Statistica 10.0 statistical package. Results. There was impaired MOCA test in patients with symptomatic stenosis of internal carotid artery (ICA), while improvement of this value was observed in patients with asymptomatic ICA stenosis. Patients with previous stroke had impaired short-term memory in early postoperative period. Both groups of patients were characterized by deteriorated attention and neurodynamics in early postoperative period. Postoperative cognitive dysfunction (POCD) occurred in 7 (58%) patients with symptomatic lesion of ICA and in 20 (67%) patients without previous stroke. Conclusion. Patients with MFA undergoing simultaneous CRR and CABG have impaired cognitive characteristics in early postoperative period. Early POCD is diagnosed in more than half of patients in both groups.