Aim — to evaluate left atrial function using longitudinal strain and strain rate in patients with coronary artery disease (CAD) and different types of ischemic mitral regurgitation (MR). Material and methods. The study included 116 CAD patients aged 60.9±3.1 years. There were 3 groups of patients: group 1 (n=33) with asymmetric MR jet along posteromedial commissure of the mitral valve; group 2 (n=41) with central MR jet; group 3 (n=42) without significant MR (≤1). Tissue Doppler images were obtained in apical 4-chamber position. Global longitudinal strain and strain rate of the left atrium (LA) were evaluated in all groups. Results. Patients with ischemic MR had impaired reservoir, conduit and contractile functions of left atrium compared with patients without MR. There were decreased LA strain and strain rate during the phases of reservoir and conduit in patients with ischemic MR compared with group without MR. LA function was slightly worse in patients with central MR jet compared with asymmetric jet, but these differences were not significant. Active atrial contraction was characterized by reduced negative global strain and late-diastolic global strain rate in patients with ischemic MR compared with patients without MR (more severe in patients with asymmetric MR jet). Conclusion. Analysis of LA global longitudinal strain and strain rate confirmed that ischemic MR is associated with impaired LA function compared with patients without MR. These disorders are caused by chronic volume overload, LA remodeling, increased stiffness of LA myocardium and impaired contractility.