Aim — to analyze an impact of somatoperceptive constitution on disease-related behavior in patients with coronary artery disease (CAD). Material and methods. Cohort study consistently included 106 (38 women and 68 men) CAD patients who were examined and treated at the Cardiology Clinic of the University’s Clinical Hospital №1 of Sechenov First Moscow State Medical University foe the period 2011—2015. All patients underwent standard cardiac and psychopathological examination; psychological testing included Shot Health Anxiety Inventor (SHAI) questionnaire, SF-36 for life quality assessment, Spielberger—Hanin assessing personal and situational anxiety (STAI). Patients were divided into groups depending on somatoperceptive constitution: group A consisted of 42 (40%) patients with neuropathy, group B — 51 (48%) patients with somatotonia, group V — 13 (12%) patients with segmental depersonalization. CAD course, disease-related behavior including compliance were analyzed. Statistical processing was carried out by using of SPSS.19. Fisher’s exact test with Bonferroni correction (significant differences were considered at p<0.013), nonparametric Kruskal—Wallace and Manna—Whitney values were calculated. Results. Significant differences in course of disease were found in all groups: favorable course was observed in 100% of cases of somatotonic constitution, unfavorable course was in 85% of segmental depersonalization and in 21% of neuropathy (subgroup A1) vs. 79% of favorable course (subgroup A2). Psychopathological examination showed predominant anxious hypochondriacal reactions in subgroup A1, neurotic hypochondria — in A2, silent and aberrant hypochondria in groups B and V, respectively. There was significant correlation of CAD course and disease-related behavior with the level of anxiety about health by SHAI questionnaire: in average and moderately elevated scores adaptive behavior was observed (subgroup A2 and group B), high — disadaptive «health-saving» (subgroup A1), low — disadaptive «ignoring» (group B).