Aminocaproic vs. tranexamic acid in cardiac surgery: what? where? when? Part 2

Charnaia M.A.; Dement'eva I.I.; Goncharova A.V.; Isaeva A.M.

doi:https://doi.org/10.17116/kardio20169451-54

Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Dement'eva I.I.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Goncharova A.V.

Petrovsky National Research Centre of Surgery, 119991, Abrikosovsky, 2, Moscow, Russia

Isaeva A.M.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Aminocaproic vs. tranexamic acid in cardiac surgery: what? where? when? Part 2

Authors:

Charnaia M.A., Dement'eva I.I., Goncharova A.V., Isaeva A.M.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(4): 51‑54

DOI: 10.17116/kardio20169451-54

Read: 2446 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Charnaia MA, Dement'eva II, Goncharova AV, Isaeva AM. Aminocaproic vs. tranexamic acid in cardiac surgery: what? where? when? Part 2. Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(4):51‑54. (In Russ.)
https://doi.org/10.17116/kardio20169451-54

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

Close metadata

Abstract:

Aim - to compare the effectiveness of aminocaproic and tranexamic acids in reducing of drainage volume after cardiac surgery. Material and methods. We retrospectively analyzed 1633 medical histories of cardiac patients who were operated in Petrovsky Russian Research Center of Surgery for the period 2012-2014. Patients were divided into 2 group depending on the intraoperative type of lysine analogue. There were tranexamic («Moscow Endocrine Factory», Russia) and aminocaproic («Moskhimfarmpreparaty», Russia) acids in groups 1 (n=927) and 2 (n=706) respectively. Both drugs were administered in prolonged infusion 10 mg/kg/h for tranexamic acid and 20 g for aminocaproic acid. Drainage volume was assessed in all patients after 6 and 12 hours postoperatively. Results. It was observed similar hemostatic effect of prolonged intraoperative administration of tranexamic (10 mg/kg/h) and aminocaproic (20 g) acids. The same hemostatic effectiveness was obtained also in different perfusion features (CPB time and temperature) and types of cardiac and aortic operations. The number of re-sternotomy for bleeding did not significantly differ in both groups.

Keywords:

fibrinolysis

fibrinolysis inhibitors

coagulopathy

postoperative bleeding

Authors:

Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Dement'eva I.I.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Goncharova A.V.

Petrovsky National Research Centre of Surgery, 119991, Abrikosovsky, 2, Moscow, Russia

Isaeva A.M.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Close metadata

References:

Mainery P, Covaia G, Realini M, et al. Postoperative bleeding after coronary revascularization. Comparison between tranexamic acid and epsilon-aminocaproic acid. Minerva Сardioangiol. 2000;48(6):155-160.
Pinsky ML, Kennedy DJ, Fishman RL, et al. Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo. J Cardiac Surg. 1997;12(5):330-338.
Hardy J-F, Belisle S, Dupont C, et al. Prophylactic tranexamic acid and epsilon-aminocaproic acid for primary myocardial revascularization. Ann Thorac Surg. 1998;65(2):371-376.
Chauhan S, Das SN, Bisoi A, et al. Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery. J Cardiothorac Vasc Anesth. 2004;18 (2):141-143.
Dement'eva I.I., CHarnaya M.А., Morozov YU.А. Sistema gemostaza pri operatsiyakh na serdtse I magistral'nykh sosudakh. M.: GEHOTАR-Media. 2009.(in Russian)
Morozov YU.А., CHarnaya M.А., Dement'eva I.I., Gladysheva V.G. Fibrinolysis system in operations with cardiopulmonary bypass. Problemy gematologii i perelivaniya krovi. 2005;2:53-57. (in Russian)
Roy S, Saha K, Mukherjee K, et al. Activation of Coagulation and Fibrinolysis During Coronary Artery Bypass Grafting: A Comparison Between On-Pump and Off-Pump Techniques. Indian J Hematol Blood Transfus. 2014;30(4):333-341. doi: 10.1007/s12288-013-0250-7
Jimenez Rivera JJ, Iribarren JL, Raya JM, et al. Factors associated with excessive bleeding in cardiopulmonary bypass patients: a nested case-control study. J Cardiothorac Surg. 2007;10: 2-17.
Engelman RM, Pleet AB, Rousou JA, et al. What is the best perfusion temperature for coronary revascularization? J Thorac Cardiovasc Surg. 1996;112:1622-1632.
Engelman RM, Pleet AB, Rousou JA, et al. The influence of cardiopulmonary bypass perfusion temperature on neurologic and hematologic function after coronary artery bypass grafting. Ann Thorac Surg. 1999;12:46-49.
Mora Mangano C, Neville M, Ping H, et al. Aprotinin, blood loss, and renal dysfunction in deep hypothermic circulatory arrest. Circulation. 2001;104:I276-1281.
Espana F, Esrelles A, Griffin J, et al. Aprotinin is a competitive inhibitor of activated protein C. Thromb Res. 1989;56:751-756.
Makhija N, Sarupria A, Kumar Choudhary S, et al. Comparison of epsilon aminocaproic acid and tranexamic acid in thoracic aortic surgery: clinical efficacy and safety. J Cardiothorac Vasc Anesth. 2013;27(6):1201-1207. doi: 10.1053/j.jvca.2013.04.003
Falana O, Patel G. Efficacy and safety of tranexamic acid versus ε-aminocaproic acid in cardiovascular surgery. Ann Pharmacother. 2014;48(12):1563-1569. doi: 10.1177/1060028014549558
Martin K, Breuer T, Gertler R, et al. Tranexamic acid versus ε-aminocaproic acid: efficacy and safety in paediatric cardiac surgery. Eur J Cardiothorac Surg. 2011;39(6):892-897. doi: 10.1016/j.ejcts.2010.09.041
Choudhuri P, Biswas BK. Intraoperative Use of Epsilon Amino Caproic Acid and Tranexamic Acid in Surgeries Performed Under Cardiopulmonary Bypass: a Comparative Study To Assess Their Impact On Reopening Due To Postoperative Bleeding. Ethiop J Health Sci. 2015;25(3):273-278.