Aminocaproic vs. tranexamic acid in cardiac surgery: what? where? when? Part 2

Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Dement'eva I.I.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Goncharova A.V.

Petrovsky National Research Centre of Surgery, 119991, Abrikosovsky, 2, Moscow, Russia

Isaeva A.M.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Aminocaproic vs. tranexamic acid in cardiac surgery: what? where? when? Part 2

Authors:

Charnaia M.A., Dement'eva I.I., Goncharova A.V., Isaeva A.M.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(4): 51‑54

DOI: 10.17116/kardio20169451-54

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To cite this article:

Charnaia MA, Dement'eva II, Goncharova AV, Isaeva AM. Aminocaproic vs. tranexamic acid in cardiac surgery: what? where? when? Part 2. Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(4):51‑54. (In Russ.)
https://doi.org/10.17116/kardio20169451-54

Подписка 2025 (Russian Journal of Cardiology and Cardiovascular Surgery)

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Aim - to compare the effectiveness of aminocaproic and tranexamic acids in reducing of drainage volume after cardiac surgery. Material and methods. We retrospectively analyzed 1633 medical histories of cardiac patients who were operated in Petrovsky Russian Research Center of Surgery for the period 2012-2014. Patients were divided into 2 group depending on the intraoperative type of lysine analogue. There were tranexamic («Moscow Endocrine Factory», Russia) and aminocaproic («Moskhimfarmpreparaty», Russia) acids in groups 1 (n=927) and 2 (n=706) respectively. Both drugs were administered in prolonged infusion 10 mg/kg/h for tranexamic acid and 20 g for aminocaproic acid. Drainage volume was assessed in all patients after 6 and 12 hours postoperatively. Results. It was observed similar hemostatic effect of prolonged intraoperative administration of tranexamic (10 mg/kg/h) and aminocaproic (20 g) acids. The same hemostatic effectiveness was obtained also in different perfusion features (CPB time and temperature) and types of cardiac and aortic operations. The number of re-sternotomy for bleeding did not significantly differ in both groups.

Keywords:

fibrinolysis

fibrinolysis inhibitors

coagulopathy

postoperative bleeding

Authors:

Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Dement'eva I.I.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Goncharova A.V.

Petrovsky National Research Centre of Surgery, 119991, Abrikosovsky, 2, Moscow, Russia

Isaeva A.M.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

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