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Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Dement'eva I.I.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Aminocaproic or tranexamic acid in cardiac surgery: what? where? when? Literature review. Part 1

Authors:

Charnaia M.A., Dement'eva I.I.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(3): 72‑77

DOI: 10.17116/kardio20169372-77

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AMINOCAPROIC OR TRANEXAMIC ACID IN CARDIAC SURGERY: WHAT? WHERE? WHEN? LITERATURE REVIEW. PART 1
AMINOCAPROIC OR TRANEXAMIC ACID IN CARDIAC SURGERY: WHAT? WHERE? WHEN? LITERATURE REVIEW. PART 1

To cite this article:

Charnaia MA, Dement'eva II. Aminocaproic or tranexamic acid in cardiac surgery: what? where? when? Literature review. Part 1. Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(3):72‑77. (In Russ.)
https://doi.org/10.17116/kardio20169372-77

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
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Abstract:

Keywords:

fibrinolysis
fibrinolysis inhibitors
coagulopathy
postoperative bleeding

Authors:

Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Dement'eva I.I.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Close metadata

References:

  1. Dement'eva I.I., CHarnaya M.А., Morozov YU.А., i dr.. Safe use of antifibrinolytic drugs in cardiac surgery: Myth or Reality? Kardiologiya i serdechno-sosudistaya khirurgiya. 2009;2:6:69-71.(in Russian)
  2. Dement'eva I.I., CHarnaya M.А., Morozov YU.А. Sistema gemostaza pri operatsiyakh na serdtse I magistral'nykh sosudakh: narusheniya, profilaktika, korrektsiya. M.: GEHOTАR-Media. 2009;154-210.(in Russian)
  3. Morozov YU.А., CHarnaya M.А., Gladysheva V.G. Influence of aminocaproic acid and low dose of trasylol on blood loss after surgery with cardiopulmonary bypass. Аnesteziologiya i reanimatologiya. 2005;4:58-60.(in Russian)
  4. CHarnaya M.А., Morozov YU.А., Gladysheva V.G., Babalyan G.V. Violation of platelet hemostasis as a cause of increased bleeding after cardiac surgery with cardiopulmonary bypass. Tromboz, gemostaz i reologiya. 2003;1:66-69.(in Russian)
  5. CHarnaya M.А., Morozov YU.А., Rojtman E.V., Gladysheva V.G., Isaeva А.M. Causes of increased bleeding after cardiac surgery with cardiopulmonary bypass. Grudnaya i serdechno-sosudistaya khirurgiya. 2003;5:41-46. (in Russian)
  6. Armellin G, Vinciguerra A, Bonato R, et al. Tranexamic acid in primary CABG surgery: high vs low dose. Minerva Anesthesiol. 2004;70(3):97-107.
  7. Arom KV, Emery RW. Decreased postoperative drainage with addition of epsilon-aminocaproic acid before cardiopulmonary bypass. Ann Thorac Surg. 1994;57(5):1108-1112.
  8. Baric D, Biocina B, Unic D, et al. Topical use of antifibri nolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. Eur J Cardiothorac Surg. 2007;31(3): 666-671.
  9. Bennett-Guerrero E, Sorohan JG, Canada AT, et al. e-Aminocaproic acid plasma levels during cardiopulmonary bypass. Anesth Analg. 1997;83(6):1189-1192.
  10. Brown JR, Birkmeyer NJO, O’Connor GT. Metaanalysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation. 2007;115:2801-2813.
  11. Butterworth J, James RL, Lin Y, et al. Pharmacokinetics of epsilon- aminocaproic acid in patients undergoing aortocoronary bypass surgery. Anesthesiology. 1999;90(6):1624-1635.
  12. Butterworth J, James RL, Lin YA, et al. Gender does not influence epsilon-aminocaproic acid concentration in adults undergoing cardiopulmonary bypass. Anesth Analg. 2001;92(6):1384-1390.
  13. Carr MEJr. Control of perioperative bleeding: Pharmacologic agents, pharmacologic management of perioperative bleeding. Ed. Wechler AS. Southampton, NY, CME Network Publishing. 1996;28-34.
  14. Casati V, Bellotti F, Gerli C, et al. Tranexamic acid administration after cardiac surgery: a prospective, randomized, double-blind, placebo-controlled study. Anesthesiology. 2001;94(1):8-14.
  15. Casati V, Della Valle P, Benussi S, et al. Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: comparison between on pump and off-pump techniques. J Thorac Cardiovasc Surg. 2004;128(1):83-91.
  16. Casati V, Gerli C, Franco A, et al. Tranexamic acid in of-pump coronary surgery: a preliminary, randomized, double- blind, placebo-controlled study. Ann Thorac Surg. 2001;72(2):470-475.
  17. Chandler WL, Fitch JCK, Wall MH, et al. Individual variations in the fibrinolytic response during and after cardiopulmonary bypass. Thromb Haemost. 1995;74:1293-1297.
  18. Chauhan S, Das SN, Bisoi A, et al. Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery. J Cardiothorac Vasc Anesth. 2004;18(2):141-143.
  19. Fanashawe MP, Shore-Lesserson L, Reich DL. Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest. Anesthesiology. 2001;95(6):1525-1527.
  20. Ferqusson DA, Hebert PC, Mazer CD, et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Eng J Med. 2008;358(22):2319-2331.
  21. Fiechter BK, Nuttall GA, Jonson ME. Plasma tranexamic acid concentration during cardiopulmonary bypass. Anesth Analg. 2001;92:1131-1136.
  22. Frederiksen MC, Bowsher DJ, Ruo TI, et al. Kinetics of epsilon aminocaproic acid distribution, elimination and antifibrinolytic effects in normal subjects. Clin Pharmacol Ther. 1984;35:387-393.
  23. Furtmuller R, Schlag MG, Berger M, et al. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect. J Pharmacol Exp Ther. 2002;301:168-173.
  24. Gram J, Janetzko T, Jespersen J, Bruhn H. Enhanced effective fibrinolysis following the neutralization of heparin in open heart surgery increases the risk of post-surgical bleeding. Thromb Haemost. 1990;63:241-245.
  25. Hardy J-F, Belisle S, Dupont C, et al. Prophylactic tranexamic acid and epsilon-aminocaproic acid for primary myocardial revascularization. Ann Thorac Surg. 1998;65(2):371-376.
  26. Hardy J-F, Desroches J. Natural and synthetic antifibrinolyticsin cardiac surgery. Can J Anaesth. 1992;39:353-365.
  27. Henry DA, Moxey AJ, Carless PA. Antifibrinolytic use for minimizing perioperative allogenic blood transfusion. Cochrane Database Syst Rev. 2001;1:CD001886.
  28. Horrow J, Hlavacek J, Strong M, et al. Prophylactic tranexamic acid decreases bleeding after cardiac surgery. J Thorac Cardiovsc Surg. 1990;99:70-74.
  29. Horrow JC. Management of coagulopathy associated with cardiopulmonary bypass. In book: Cardiopulmonary bypass: Principles and Practice. Ed. Gravlee GP, et al. Baltimore: Williams and Wilkins. 1993;436-466.
  30. Horrow JC, van Ripper DF, Strong MD, et al. The dose-response relationship of tranexamic acid. Anesthesiology. 1995;82:383-392.
  31. Jares M, Vanek T, Straka Z, Brucek P. Tranexamic acid reduced bleeding after off-pump coronary artery bypass grafting. J Cardiovasc Surg. 2003;44(2):205-208.
  32. Jimenez JJ, Iribarren JL, Lorente L, et al. Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial. Crit Care. 2007;11(6):R117.
  33. Karski JM, Dowd NP, Joiner R, et al. The effect of three different doses of tranexamic acid on blood loss after cardiac surgery with mild systemic hypothermia (32 degrees C). J Cardiothorac Vasc Anesth. 1998;12:642-646.
  34. Karski JM, Teasadale SJ, Norman P, et al. Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid. Double-blind, randomized clinical trial. J Thorac Cardiovasc Surg. 1995;110:835-842.
  35. Kluger R, Olive DJ, Stewart AB, et al. Epsilon-aminocaproic acid in coronary artery bypass graft surgery: preincision or postheparin? Anesthesiology. 2003;99:1263-1269.
  36. Kuitunen AH, Suojaranta-Ylinen RT, Kukkonen SI, et al. Tranexamic acid not correct the haemostatic impairment caused by hydroxyethil starch (200 kDa/0,5) after cardiac surgery. Blood Coag Fibrinolysis. 2006;17(8):639-645.
  37. Lambert CJ, Marengo-Rowe AJ, Leveson JE, et al. The treatment of postperfusion bleeding using epsilon- aminocaproic acid, cryoprecipitate, fresh-frozen plasma, and protamine sulfate. Ann Thorac Surg. 1979;28(5):440-444.
  38. Maineri P, Covaia G, Realini M, Caccia G, Ucussich E, Luraschi M, Crosta A, Foresti B, Chiaranda M. Postoperative bleeding after coronary revascularization. Comparision between tranexamic acid and epsilon-aminocapronic acid. Minerva Cardioangiol. 2000;48(6):155-160.
  39. Martin K, Knorr J, Breuer T, et al. Seizures after open heart surgery: comparison of e-aminocaproic acid and tranexamic acid. J Cardiothorac Vasc Anesth. 2011;25:20-25.
  40. McNicol GP, Fletcher AP, Alkjaersig N, Sherry S. The absorption, distribution and excretion of epsilon aminocaproic acid following oral or intra venous administration to man. Lab Clin Med. 1962;59:15-24.
  41. Menkis AH, Martin J, Cheng DC, et al. Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011. Innovations (Phila). 2012;7(4):229-241.
  42. Miashita T, Kamibayashi T, Ohnishi Y, et al. Preservation of collagen- induced whole blood platelet aggregation by tranexamic acid therapy in primary cardiac valve surgery. Perfusion. 2000;15(6):507-513.
  43. Montes FR, Pardo DF, Carreno M, et al. Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: a case-control study. Ann Card Anaesth. 2012;15:6-12.
  44. Montesano RM, Gustafson PA, Palanzo DA, et al. The effect of low-dose epsilon-aminocaproic acid on patients following coronary artery bypass surgery. Perfusion. 1996;11(1):53-56.
  45. Murkin JM, Falter F, Grantan J. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg. 2010;110:350-353.
  46. Ovrum E, Am Holen E, Abdelnoor M, et al. Tranexamic acid (Cyklokapron) is not necessary to reduce loss after coronary artery bypass operations. J Thorac Cardiovasc Surg. 1993;105(1):78-83.
  47. Ozier Y. Pharmacological approaches to redusing blood loss and transfusions in the surgical patient. Can J Anesth. 2006;53(6):S21-S29.
  48. Pinsky ML, Kennedy DJ, Fishman RL, et al. Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo. J Cardiac Surg. 1997;12(5):330-338.
  49. Pleym H, Stenseth R, Wahba A, et al. Single-dose tranexamic acid reduced postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesth Analg. 2003;94(4):923-928.
  50. Ravindranat T, Raghuram CG, Suredar Reddy G, et al. Does the efficacy of epsilon aminocaproic acid vary with the duration of cardiopulmonary bypass. Indian J Anaesth. 2004;48(1):50-53.
  51. Ray MJ, Marsh NA, Hanson GA. Relationship of fibrinolysis and platelet function to bleeding after cardiopulmonary bypass. Blood Coagul Fibrinolysis. 1994;5:679-685.
  52. Ririe DG, James RL, O’Brien JJ, et al. The pharmokinetics of epsilon-aminocaproic acid in children undergoing surgical repair of congenital heart defects. Anesth Analg. 2002;94(1):44-49.
  53. Saffitz JE, Stahl DJ, Sundt TM, et al. Disseminated intravascular coagulation after administration of aprotinin in combination with deep hypothermic circulatory arrest. Am J Cardiol. 1993;72:1080-1082.
  54. Sandeep C, Akshay KB, Beeraka HR, et al. Dosage of epsilonaminocaproic acid to reduse postoperative blood loss. Asian Cardiovasc Thorac Ann. 2000;8:15-18.
  55. Sander M, Spies CD, Martiny V, et al. Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis. Crit Care. 2010;14(4):R148.
  56. Slaughter TF, Faghih F, Greenberg CS, et al. The effects of epsilon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery. Anesth Analg. 1997;85(6):1221-1226.
  57. Sterns LP, Lillehei CW. Effect of epsilon aminocaproic acid upon blood loss following open heart surgery: an analysis of 340 patients. Can J Surg. 1967;10:304-307.
  58. Vacharaksa K, Prakanrattana U, Suksompong S, Chumpathong S. Tranexamic acid as a means of reducing the need for blood and blood component therapy in children undergoing open heart surgery for congenital cyanotic heart disease. J Med Assoc Thai. 2002;85(Suppl. 3):904-909.
  59. Wong BI. Synthetic antifibrinilytics and aprotinin for cardiac surgery. In book: Management of bleeding in cardiovascular surgery. Ed. Piffare R. Philadelphia: Hanley&Belfus Inc. 2002;261-278.
  60. Yasim A, Asik R, Atahan E. Effect of topical applications of aprotinin and tranexamic acid on blood loss after open heart surgery. Anadolu Kardiyol Derg. 2005;5(1):36-40
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